Bone Marrow Aspirate Concentrate and Expanded Stem Cell Applications in Orthopaedics

Basic Sciences Behind BMAC and Expanded Stem Cells

Author(s): Mohamed Ahmed Mandour, Asmaa Kamal Abdel Maogood, Eman Gamal Ahmed and Rania Mohammed Kishk

Pp: 5-21 (17)

Doi: 10.2174/9781681086491118010007

* (Excluding Mailing and Handling)


Bone Marrow (BM) is a major hematopoietic organ in the human body being the main primary lymphoid organ; it is the source of production of all blood lineages. These cells are produced through an interaction between BM hematopoietic cells and the surrounding microenvironment in a unit called the stem cell niche that involves several cytokines, growth factors and transcriptional factors. The following chapter will entail an overview of MSCs, their isolation and clinical application.

Keywords: Basic Science, Bone Marrow Aspirate, Bone Marrow Aspirate Concentrate (BMAC), Expanded stem cells, MSCs, Stem cell differentiation.

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