Bone Marrow (BM) is a major hematopoietic organ in the human body being the main primary lymphoid organ; it is the source of production of all blood lineages. These cells are produced through an interaction between BM hematopoietic cells and the surrounding microenvironment in a unit called the stem cell niche that involves several cytokines, growth factors and transcriptional factors. The following chapter will entail an overview of MSCs, their isolation and clinical application.
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Cite this chapter as:Mohamed Ahmed Mandour, Asmaa Kamal Abdel Maogood, Eman Gamal Ahmed, Rania Mohammed Kishk ;
Basic Sciences Behind BMAC and Expanded Stem Cells, Bone Marrow Aspirate Concentrate and Expanded Stem Cell Applications in Orthopaedics (2018) 1: 5. https://doi.org/10.2174/9781681086491118010007
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