Medicinal Chemistry for Pharmacy Students

Volume: 1

Solubility and Lipid-Water Partition Coefficient

Author(s): Hardeep Singh Saluja and M. O. Faruk Khan

Pp: 109-130 (22)

DOI: 10.2174/9781681086873118010007

* (Excluding Mailing and Handling)


This chapter is brief review of solubility and related concepts, lipid-water partition coefficients and their significance in drug bioavailability. After study of this chapter, students will be able to: • Analyze and predict the solubility of drugs. • Identify factors affecting the solubility of drugs. • Project the polarity, hydrophilicity, hydrophobicity, lipophilicity of drugs and their influence on solubility. • Predict the water or lipid solubility of drugs from their structures. • Comprehend the concept of partition coefficient. • Apply the concept of lipid water partition coefficient (LWPC) and its significance in drug bioavailability and action.

Keywords: Hydrophobicity, Hydrophilicity, Lipid-water partition coefficient, Lipophilicity, Solubility, Water solubilizing potential.

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