Preclinical and Clinical Experiments on HPV Vaccines

Abstract

Persistent infection with human papillomavirus (HPV) is a key factor in the development of precancerous lesions and invasive cervical cancer. Prophylactic vaccines are an effective approach to reduce HPV-related disease burden. Regarding the studies, at least 110-120 countries have implemented Cervarix™ and Gardasil™ for induction of protective effects against HPV infections. On the other hand, several clinical trials are underway for therapeutic HPV vaccination. Special approaches is considered to increase the potency of therapeutic vaccines including the use of effective adjuvant, selection of strong immunogen and combination therapies to overcome tumor immune suppression. In this chapter, we will summarize main preventive and therapeutic HPV vaccines in preclinical and clinical trials.

Keywords: Clinical study, HPV infection, Preclinical study, Prophylactic vaccine, Therapeutic vaccine.Clinical study, HPV infection, Preclinical study, Prophylactic vaccine, Therapeutic vaccine.