Differences in prevalence rates of HPV infections are observed worldwide. Cervical cancer remains a major public health concern, especially in developing countries. Cancers of the anus, penis, vagina, and vulva are relatively uncommon cancers, but their incidence is gradually increasing in the world. Indeed, the epidemiology of HPV-associated anogenital cancers of the cervix, anus, penis, vagina and vulva is changing, likely due to increasing HPV transmission secondary to changes in sexual behaviour. Molecular epidemiologic studies indicate that certain HPV types were highly prevalent among women aged below 30 years with a peak in the 21-25 year age group and those who are above 30 years. Thus, screening programs and the HPV vaccines are required to prevent the anogenital cancers. In this chapter, the epidemiology of HPV-related cancer types will be studied based on new data.