Frontiers in Clinical Drug Research: HIV

Volume: 4

The Development and Clinical Progress on Chemokine Receptor-Based HIV Entry Inhibitors

Author(s): Yi-Qun Kuang

Pp: 105-137 (33)

DOI: 10.2174/9781681085265119040006

* (Excluding Mailing and Handling)


Entry of HIV-1 into targeted host cells is a highly ordered multistage process involving first-receptor attachment, co-receptor binding, and membrane fusion. In this chapter, I will present an overview of progress on HIV-1 entry inhibitors with a focus on chemokine receptor-based antagonists. This chapter, at first, will describe the working mechanisms of chemokine receptors, HIV-1 co-receptors CCR5 and CXCR4, during the replication procedure. Then, the antagonists-based on different mechanisms will be presented in detail. At last, it will summarize and explain the distinct promising entry inhibitors based on co-receptors-interacting proteins, which is inspired by our current work.

Keywords: AIDS, CCR5, Chemokine receptor, Co-receptor, CXCR4, Entry inhibitor, HIV.

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