In this chapter, we review the current concepts about Nesfatin-1 as a new anti-obesity treatment and evaluate the existing issues about this knowledge and the available literature. The intent is to inform clinicians about Nesfatin-1 as a new kind of anti-obesity treatment and make a rational decision based on this perspective as possible clinical application. It can be potentially helpful in the therapy of metabolic disorders and obesity of various origins. In fact, the details of nesfatin-1 physiology could be clarified, and it may be considered suitable in the future as a potential drug in the pharmacotherapy of obesity, due to its anorexigenic effects, and as a new potential modulator of appetite in the therapy of eating disorders such as anorexia nervosa by using selective nesfatin-1 antagonists. Therefore, further progress of pharmacological researches in this field is still very limited. Further research on this topic certainly merit attention.