

Targeting Enzymes For Cancer Therapy
Journal: Anti-Cancer Agents in Medicinal Chemistry
Guest Editor(s): Dr. Guang Huang
Co-Guest Editor(s):
Submission closes on:
26th January, 2026
Introduction
Enzymes are essential to numerous cellular processes, and their dysregulation often drives tumor progression and metastasis. Consequently, targeting specific enzymes has emerged as a promising therapeutic approach in oncology. This thematic issue, Targeting Enzymes for Cancer Therapy, will explore the latest advancements and challenges in the discovery, development, and application of enzyme-targeted treatments for various cancers. The issue will feature articles on a diverse array of topics, including the innovative design and synthesis of enzyme inhibitors and degraders, bioactivity evaluations, and their potential therapeutic applications in oncology. By showcasing cutting-edge strategies and methodologies, this issue aims to engage researchers in medicinal chemistry, biochemistry, and drug development. We invite high-quality reviews and original research articles for this Special Issue, which aspires to be a valuable resource for advancing enzyme-based cancer therapies.
Keywords
Enzymes, Kinases, Cancer, Anticancer, Drug design and discovery, Inhibitors, Degraders, Mechanism.
Sub-topics
- Design, synthesis, and discovery of enzyme inhibitors and degraders
- Structural and mechanistic insights into enzymes as cancer targets
- Novel therapeutic approaches targeting kinases, histone methyltransferases, deacetylases, and other critical enzymes involved in cancer pathways
- Advances in computational methods and high-throughput screening to identify enzyme-targeted lead/drug candidates
- Advances in Medicinal Chemistry
- Application of privileged scaffolds in drug design and development