Biomolecules in Medicinal and Pharmaceutical Chemistry for Drug Development

Introduction

Medicinal chemists play a vital role in the drug development process by identifying and synthesizing molecules that define structure-activity correlations and ensure efficacy and safety in preclinical animal testing. The fields of medicinal chemistry and pharmaceutical chemistry constitute an analogy that has the potential to encourage a beneficial relationship between ecosystems, development, and physical wellness. The design, optimization, and development of new chemical compounds that could be utilized as drugs are the major focuses of these multidisciplinary issues. Drug development and discovery comprises preclinical research with cell-based and animal models, clinical studies on humans, and subsequent progress to maintaining approval from regulators for marketing the drug. Biomolecules are fundamental organic compounds that play critical roles in regulating diverse physiological and metabolic functions in living organisms. Biomolecules are the essential components of all living things. Each organism undergoes several chemical and redox reactions that assist involuntary responses. A wide range of important and life-saving drugs allow people to live longer and healthier lives. The process of developing a novel pharmaceutical and promoting it for human use is lengthy, comprising evaluations of its physical, chemical, and biological properties, as well as its efficacy, stability, and pharmacokinetic features. This Special Issue focuses on recent advances in biomolecules for computational, pharmaceutical, and medicinal chemistry including new synthetic and natural compounds with potential significance as antimicrobial/therapeutic agent(s) for drug development. Original research articles, reviews, mini-reviews, and perspectives are welcomed in this issue.

Keywords

Biomolecules, synthesis, antimicrobial, computational chemistry, medicinal chemistry, pharmacokinetics, molecular docking/dynamics, biomolecule-based drugs, computational biology

Sub-topics

• Synthesis of biomolecule molecules and determination of their structure
• Drug synthesis and drug discovery
• Pharmaceutical and Medicinal Chemistry
• Biomolecule-based drug development
• Computational and Theoretical Chemistry
• Antimicrobial activity for potential therapeutic interest
• Antivirals, antifungals, antiparasitics, antimalarial, antitumor, antibiotics, and antiprotozoals activities
• Theoretical studies (drug-likeness, qualitative structural-activity relationship (QSAR) analysis, ADME/toxicity, molecular docking, and molecular dynamics)
• Biological active molecules
• Computational biology
• Drug-targeted medicine
• Quantum computational investigations
• Conformational modeling (small molecules/macromolecules)
• Biological evaluation of small or/macromolecules