New Strategies for Targeting Regulated Cell Death Signals in Ischemia-Reperfusion Injury-Related Diseases: New Findings and Mechanism Research

Introduction

Ischemia-reperfusion injury (I/R) occurs during reperfusion after ischemia, which not only fails to restore tissue and organ function, but rather exacerbates tissue damage, and occurs in a wide range of organs and tissues, including the brain, heart, kidneys, liver, and retina. I/R injury involves a variety of pathological processes, such as regulated cell death (apoptosis, necroptosis, ferroptosis, pyroptosis, and PANoptosis), oxidative stress, inflammatory response, excitotoxicity, and calcium overload. Significantly, prevention and treatment of I/R injury is urgent, especially for regulated cell death induced by I/R. However, there is still much to be explored concerning I/R-induced regulated cell death. In these explorations, elucidating the relevant chemical mechanisms can provide strategies for clinical treatment, and searching for intervening drugs or analyzing the effects of drugs can help develop drugs. All of these studies offer hope that the problem of I/R-induced regulated cell death can be solved. We welcome submissions in the form of original research and review articles focusing on new strategies targeting regulated cell death signaling in I/R-associated diseases as well as studies on the underlying mechanisms.

Keywords

Ischemia- reperfusion injury, regulated cell death, pharmaceuticals, molecular metabolism, molecular biology, biochemistry

Sub-topics

Development of drugs, and compounds for targeting regulated cell death induced by I/R;

Regulatory mechanisms of drugs, and compounds in targeting regulated cell death induced by I/R;

Discovery of new types or mechanisms of regulated cell death in I/R related diseases;

Discovery of new molecular structure changes during I/R injury.

Discovery of new pharmacokinetics in the process of I/R injury.