Heart and Brain Axis Targets in CNS Neurological Disorders

Introduction

Recently, there has been a surge of interest in delving deeper into the complex interplay between the heart and brain. This fascination stems from a growing recognition of the profound influence each organ holds over the other, particularly in the realm of central nervous system and neurological disorders. The purpose of this special issue is to meticulously explore and elucidate the identification and characterization of therapeutic targets that have the capacity to influence both cardiac and cerebral functions. By honing in on these targets, this issue aims to provide a thorough and expansive understanding of the intricate relationship shared by these vital organs. Through comprehensive analysis, the issue will uncover the potential implications of this relationship in the progression of various neurological disorders. This issue aims to inspire not only to enrich our understanding of the physiological connection between the heart and brain but also to pave the way for innovative therapeutic interventions that can revolutionize the treatment landscape for such disorders.

Keywords

Heart-Brain Axis, Neurovascular Coupling, Blood-Brain Barrier, Cardiovascular Risk Factors, Psychocardiology, Neurogenic Heart Disorders, Inflammation, Oxidative Stress, Neurobiology of Heart Failure, Dual-Targeted Therapeutics

Sub-topics

• Neurovascular coupling and its implications for the treatment of CNS disorders


• The role of the blood-brain barrier in the pathogenesis of neurological disorders and drug action mechanisms


• Shared molecular mechanisms and signaling pathways between the heart and brain that affects treatment efficiency and specificity


• The impact of cardiovascular risk factors on the development and progression of CNS disorders


• Impact of stress and emotion on cardiac health: role of the brain-heart axis in psychocardiology


• Neurological complications of cardiovascular diseases: stroke, cognitive impairment, and neurodegeneration


• Heart-brain interactions in aging and age-related diseases


• Neurogenic heart disorders: Takotsubo syndrome, neurocardiogenic syncope, and autonomic dysregulation


• Role of inflammation, oxidative stress, and neurohormonal signaling


• Neurobiology of heart failure: implications for cognitive function and quality of life


• Translational research and clinical implications of brain-heart axis modulationo Dual-Targeted Therapeutic strategies targeting both the heart and brain for the treatment of CNS disorders