Pathogenic Proteins in Neurodegenerative Diseases: From Mechanisms to Treatment Modalities

Introduction

The primary objective of this thematic issue is to elucidate the molecular mechanisms by which pathogenic proteins contribute to neurodegenerative diseases and to highlight current and emerging therapeutic strategies aimed at mitigating their effects. By bringing together cutting-edge research and reviews, this issue aims to: 1.Enhance Understanding: Provide a comprehensive overview of the molecular pathways involved in the pathogenesis of neurodegenerative diseases. 2.Highlight Innovations: Showcase recent advancements in therapeutic interventions targeting pathogenic proteins. 3.Foster Collaboration: Encourage interdisciplinary research and collaboration in the field of neurodegenerative diseases. 4.Promote Translation: Bridge the gap between basic research and clinical application, promoting the development of effective therapies. This thematic issue will provide a comprehensive and up-to-date overview of the field, encompassing both basic research and translational studies. By focusing on the molecular mechanisms of pathogenic proteins and the latest therapeutic strategies, this collection aims to foster a deeper understanding of neurodegenerative diseases and inspire new approaches to treatment. By compiling contributions from leading researchers and clinicians, this thematic issue will serve as an invaluable resource for scientists, healthcare professionals, and policymakers, ultimately contributing to the advancement of research and the development of effective therapies for neurodegenerative diseases.

Keywords

Neurodegenerative Diseases, Pathogenic Proteins, Molecular Mechanisms, Therapeutic Interventions, Alzheimer's Disease

Sub-topics

List of Sub-Topics for the Issue

1. Molecular Pathways of α-Synuclein in Parkinson's Disease


2. Tau Pathology and Neurodegeneration in Alzheimer's Disease


3. Role of Beta-Amyloid in Alzheimer's Disease: Mechanisms and Therapeutic Targets


4. TDP-43 Proteinopathies in ALS and FTLD


5. Genetic and Molecular Insights into C9orf72-Linked Neurodegeneration


6. FUS Protein in ALS: Mechanisms and Potential Therapeutic Approaches


7. Progranulin and Its Role in Frontotemporal Lobar Degeneration


8. Mechanisms of Protein Aggregation and Toxicity in Neurodegenerative Diseases


9. Small Molecule Inhibitors Targeting Pathogenic Protein Aggregation


10. Monoclonal Antibodies and Immunotherapies for Neurodegenerative Disorders


11. Gene Therapy Approaches for Neurodegenerative Diseases


12. RNA-Based Therapies Targeting Pathogenic Proteins


13. Enhancing Proteasomal and Lysosomal Degradation of Pathogenic Proteins


14. The Role of Autophagy in Mitigating Neurodegenerative Proteinopathies


15. Combination Therapies: Integrating Multiple Strategies to Combat Neurodegenerative Diseases