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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Treatment of Recurrent Epistaxis in HHT

Author(s): U. W. Geisthoff, M. L. Fiorella and R. Fiorella

Volume 12, Issue 10, 2006

Page: [1237 - 1242] Pages: 6

DOI: 10.2174/138161206776361255

Price: $65


No optimal treatment modality is currently available for the treatment of recurrent epistaxis in HHT. In this review, different therapeutic concepts are discussed together with their pathophysiologic background. Patients often profess a preventive effect for nasal ointments and use packings which can be self-administed in the case of bleeding. An effective first-line treatment for physicians is the endonasal laser coagulation or argon plasma coagulation. A second line surgical procedure is septodermoplasty according to Saunders which can provide long-lasting relief if performed correctly. There have been reports on antifibrinolytic agents and hormones, but their efficacy has yet to be determined.

Keywords: Rendu-Osler-Weber disease, hereditary haemorrhagic telangiectasia, laser therapy, septodermoplasty, review

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