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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

The Application of Hydrogels Based on Natural Polymers for Tissue Engineering

Author(s): Yasamin Davatgaran Taghipour, Vahideh Raeisdasteh Hokmabad, Azizeh Rahmani Del Bakhshayesh, Nahideh Asadi, Roya Salehi* and Hamid Tayefi Nasrabadi*

Volume 27, Issue 16, 2020

Page: [2658 - 2680] Pages: 23

DOI: 10.2174/0929867326666190711103956

Price: $65


Hydrogels are known as polymer-based networks with the ability to absorb water and other body fluids. Because of this, the hydrogels are used to preserve drugs, proteins, nutrients or cells. Hydrogels possess great biocompatibility, and properties like soft tissue, and networks full of water, which allows oxygen, nutrients, and metabolites to pass. Therefore, hydrogels are extensively employed as scaffolds in tissue engineering. Specifically, hydrogels made of natural polymers are efficient structures for tissue regeneration, because they mimic natural environment which improves the expression of cellular behavior.

Producing natural polymer-based hydrogels from collagen, hyaluronic acid (HA), fibrin, alginate, and chitosan is a significant tactic for tissue engineering because it is useful to recognize the interaction between scaffold with a tissue or cell, their cellular reactions, and potential for tissue regeneration. The present review article is focused on injectable hydrogels scaffolds made of biocompatible natural polymers with particular features, the methods that can be employed to engineer injectable hydrogels and their latest applications in tissue regeneration.

Keywords: Hydrogel, Natural polymers, Tissue engineering, Biomaterials, Polymer-based networks, Hyaluronic acid (HA).

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