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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Composition and Potential Health Benefits of Pomegranate: A Review

Author(s): Vesna Vučić*, Milkica Grabež, Armen Trchounian and Aleksandra Arsić

Volume 25, Issue 16, 2019

Page: [1817 - 1827] Pages: 11

DOI: 10.2174/1381612825666190708183941

Price: $65

Abstract

Background: Pomegranate (Punica granatum L.) fruits are widely consumed and used as preventive and therapeutic agents since ancient times. Pomegranate is a rich source of a variety of phytochemicals, which are responsible for its strong antioxidative and anti-inflammatory potential.

Objective: The aim of this review is to provide an up-to-date overview of the current knowledge of chemical structure and potential health benefits of pomegranate.

Methods: A comprehensive search of available literature.

Results: The review of the literature confirms that juice and extracts obtained from different parts of this plant, including fruit peel, seeds, and leaves exert health benefits in both in vitro and in vivo studies. The antidiabetic, antihypertensive, antimicrobial and anti-tumour effects of pomegranate fruit are of particular scientific and clinical interest.

Conclusion: Further investigations are required to clarify the mechanism of action of the bioactive ingredients and to reveal full potential of pomegranate as both preventive and therapeutic agent.

Keywords: Pomegranate, pomegranate juice, pomegranate peel, polyphenols, antioxidant, metabolic disease, cancer, inflammatory disease.

[1]
Bhandari PR. Pomegranate (Punica granatum L). Ancient seeds for modern cure? Review of potential therapeutic applications. Int J Nutr Pharmacol Neurol Dis 2012; 2: 171-84.
[http://dx.doi.org/10.4103/2231-0738.99469]
[2]
Stepanyan-Gandilyan N. On the evolution of Punica granatum L. (Punicaceae). Takhtajania 2018; 4: 104-10.
[3]
Viuda-Martos M, Fernández-López J, Pérez-Álvarez J. Pomegranate and its many functional components as related to human health: A review. Compr Rev Food Sci Food Saf 2010; 9: 635-54.
[http://dx.doi.org/10.1111/j.1541-4337.2010.00131.x]
[4]
Aviram M, Kaplan M, Rosenblat M, Fuhrman B. Dietary antioxidants and paraoxonases against LDL oxidation and atherosclerosis development. Handb Exp Pharmacol 2005; 170(170): 263-300.
[http://dx.doi.org/10.1007/3-540-27661-0_9] [PMID: 16596803]
[5]
Gil MI, Tomás-Barberán FA, Hess-Pierce B, Holcroft DM, Kader AA. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem 2000; 48(10): 4581-9.
[http://dx.doi.org/10.1021/jf000404a] [PMID: 11052704]
[6]
Seeram NP, Aviram M, Zhang Y, et al. Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. J Agric Food Chem 2008; 56(4): 1415-22.
[http://dx.doi.org/10.1021/jf073035s] [PMID: 18220345]
[7]
Azadzoi KM, Schulman RN, Aviram M, Siroky MB. Oxidative stress in arteriogenic erectile dysfunction: Prophylactic role of antioxidants. J Urol 2005; 174(1): 386-93.
[http://dx.doi.org/10.1097/01.ju.0000161209.39959.67] [PMID: 15947695]
[8]
Rozenberg O, Howell A, Aviram M. Pomegranate juice sugar fraction reduces macrophage oxidative state, whereas white grape juice sugar fraction increases it. Atherosclerosis 2006; 188(1): 68-76.
[http://dx.doi.org/10.1016/j.atherosclerosis.2005.10.027] [PMID: 16332370]
[9]
Çam M, İçyer NC, Erdoğan F. Pomegranate peel phenolics: Microencapsulation, storage stability and potential ingredient for functional food development. Lebensm Wiss Technol 2014; 55: 117-23.
[http://dx.doi.org/10.1016/j.lwt.2013.09.011]
[10]
Singh RP, Chidambara Murthy KN, Jayaprakasha GK. Studies on the antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models. J Agric Food Chem 2002; 50(1): 81-6.
[http://dx.doi.org/10.1021/jf010865b] [PMID: 11754547]
[11]
Akhtar S, Ismail T, Fraternale D, Sestili P. Pomegranate peel and peel extracts: Chemistry and food features. Food Chem 2015; 174: 417-25.
[http://dx.doi.org/10.1016/j.foodchem.2014.11.035] [PMID: 25529700]
[12]
Fischer UA, Carle R, Kammerer DR. Identification and quantification of phenolic compounds from pomegranate (Punica granatum L.) peel, mesocarp, aril and differently produced juices by HPLC-DAD-ESI/MS(n). Food Chem 2011; 127(2): 807-21.
[http://dx.doi.org/10.1016/j.foodchem.2010.12.156] [PMID: 23140740]
[13]
Young JE, Pan Z, Teh HE, et al. Phenolic composition of pomegranate peel extracts using an liquid chromatography-mass spectrometry approach with silica hydride columns. J Sep Sci 2017; 40(7): 1449-56.
[http://dx.doi.org/10.1002/jssc.201601310] [PMID: 28139056]
[14]
Singh B, Singh JP, Kaur A, Singh N. Phenolic compounds as beneficial phytochemicals in pomegranate (Punica granatum L.) peel: A review. Food Chem 2018; 261: 75-86.
[http://dx.doi.org/10.1016/j.foodchem.2018.04.039] [PMID: 29739608]
[15]
Walid E, Hedia H, Tlili N, Yassine Y, Nizar NFA. Total phenolic contents and antioxidant activities of pomegranate peel, seed, leaf and flower. J Med Plants Res 2012; 6: 4724-30.
[16]
Yunfeng LG, Changjiang Y, Jijun W, Jingyu X, Jing CS. Evaluation of antioxidant properties of pomegranate peel extractin comparison with pomegranate pulp extract. Food Chem 2006; 2006(96): 254-60.
[17]
Wu S, Tian L. Diverse Phytochemicals and Bioactivities in the Ancient Fruit and Modern Functional Food Pomegranate (Punica granatum). Molecules 2017; 22(10)E1606
[http://dx.doi.org/10.3390/molecules22101606] [PMID: 28946708]
[18]
Gil MI, Tomás-Barberán FA, Hess-Pierce B, Holcroft DM, Kader AA. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem 2000; 48(10): 4581-9.
[http://dx.doi.org/10.1021/jf000404a] [PMID: 11052704]
[19]
Mena P, Calani L, Dall’Asta C, et al. Rapid and comprehensive evaluation of (poly)phenolic compounds in pomegranate (Punica granatum L.) juice by UHPLC-MSn. Molecules 2012; 17(12): 14821-40.
[http://dx.doi.org/10.3390/molecules171214821] [PMID: 23519255]
[20]
Akhavan H, Barzegar M, Weidlich H, Zimmermann BF. Phenolic compounds and antioxidant activity of juices from ten Iranian Pomegranate cultivars depend on extraction. J Chem 2015.907101
[21]
Legua P, Melgarejo P, Abdelmajid H, et al. Total phenols and antioxidant capacity in 10 Moroccan pomegranate varieties. J Food Sci 2012; 77(1): C115-20.
[http://dx.doi.org/10.1111/j.1750-3841.2011.02516.x] [PMID: 22260100]
[22]
Ristic-Medic D, Suzic S, Vucic V, Takic M, Tepsic J, Glibetic M. Serum and erythrocyte membrane phospholipids fatty acid composition in hyperlipidemia: Effects of dietary intervention and combined diet and fibrate therapy. Gen Physiol Biophys 2009; 28(Spec No): 190-9.
[PMID: 19893100]
[23]
Ristic-Medic D, Vucic V, Takic M, Karadžic I, Glibetic M. Polyunsaturated fatty acids in health and disease. J Serb Chem Soc 2013; 78(9): 1269-89.
[http://dx.doi.org/10.2298/JSC130402040R]
[24]
Aruna P, Venkataramanamma D, Singh AK, Singh RP. Health benefits of punicic acid: A review. Compr Rev Food Sci Food Saf 2016; 15(1): 16-27.
[http://dx.doi.org/10.1111/1541-4337.12171]
[25]
Rafiq Z, Narasimhan S, Vennila R, Vaidyanathan R. Punigratane, a novel pyrrolidine alkaloid from Punica granatum rind with putative efflux inhibition activity. Nat Prod Res 2016; 30(23): 2682-7.
[http://dx.doi.org/10.1080/14786419.2016.1146883] [PMID: 26912266]
[26]
Fischer UA, Jaksch AV, Carle R, Kammerer DR. Determination of lignans in edible and nonedible parts of pomegranate (Punica granatum L.) and products derived therefrom, particularly focusing on the quantitation of isolariciresinol using HPLC-DAD-ESI/MSn. J Agric Food Chem 2012; 60(1): 283-92.
[http://dx.doi.org/10.1021/jf203598m] [PMID: 22136560]
[27]
Hussain T, Tan B, Yin Y, Blachier F, Tossou MCB, Rahu N. Oxidative Stress and Inflammation: What Polyphenols Can Do for Us? Oxid Med Cell Longev 2016; 20167432797
[http://dx.doi.org/10.1155/2016/7432797] [PMID: 27738491]
[28]
Rodrigo R, Miranda A, Vergara L. Modulation of endogenous antioxidant system by wine polyphenols in human disease. Clin Chim Acta 2011; 412(5-6): 410-24.
[http://dx.doi.org/10.1016/j.cca.2010.11.034] [PMID: 21130758]
[29]
Tsai H-Y, Ho C-T, Chen Y-K. Biological actions and molecular effects of resveratrol, pterostilbene, and 3′-hydroxypterostilbene. Yao Wu Shi Pin Fen Xi 2017; 25(1): 134-47.
[http://dx.doi.org/10.1016/j.jfda.2016.07.004] [PMID: 28911531]
[30]
Gülçin I, Alici HA, Cesur M. Determination of in vitro antioxidant and radical scavenging activities of propofol. Chem Pharm Bull (Tokyo) 2005; 53(3): 281-5.
[http://dx.doi.org/10.1248/cpb.53.281] [PMID: 15744098]
[31]
Aloqbi A, Omar U, Yousr M, Grace M, Lila MA, Howell N. Antioxidant activity of pomegranate juice and punicalagin. Nat Sci 2016; 8: 235-46.
[http://dx.doi.org/10.4236/ns.2016.86028]
[32]
Avetisyan A, Markosian A, Petrosyan M, et al. Chemical composition and some biological activities of the essential oils from basil Ocimum different cultivars. BMC Complement Altern Med 2017; 17(1): 60.
[http://dx.doi.org/10.1186/s12906-017-1587-5] [PMID: 28103929]
[33]
Castañeda-Ovando A, Pacheco-Hernández M, Páez-Hernández ME, Rodríguez JA, Galán-Vidal CA. Chemical studies of anthocyanins: A review. Food Chem 2009; 113: 859-71.
[http://dx.doi.org/10.1016/j.foodchem.2008.09.001]
[34]
Fraga CG, Galleano M, Verstraeten SV, Oteiza PI. Basic biochemical mechanisms behind the health benefits of polyphenols. Mol Aspects Med 2010; 31(6): 435-45.
[http://dx.doi.org/10.1016/j.mam.2010.09.006] [PMID: 20854840]
[35]
Halliwell B. Reactive oxygen species in living systems: Source, biochemistry, and role in human disease. Am J Med 1991; 91(3C): 14S-22S.
[http://dx.doi.org/10.1016/0002-9343(91)90279-7] [PMID: 1928205]
[36]
Rodrigo R, Bosco C. Oxidative stress and protective effects of polyphenols: Comparative studies in human and rodent kidney. A review. Comp Biochem Physiol C Toxicol Pharmacol 2006; 142(3-4): 317-27.
[http://dx.doi.org/10.1016/j.cbpc.2005.11.002] [PMID: 16380298]
[37]
Nijveldt RJ, van Nood E, van Hoorn DE, Boelens PG, van Norren K, van Leeuwen PA. Flavonoids: A review of probable mechanisms of action and potential applications. Am J Clin Nutr 2001; 74(4): 418-25.
[http://dx.doi.org/10.1093/ajcn/74.4.418] [PMID: 11566638]
[38]
Vauzour D, Rodriguez-Mateos A, Corona G, Oruna-Concha MJ, Spencer JPE. Polyphenols and human health: prevention of disease and mechanisms of action. Nutrients 2010; 2(11): 1106-31.
[http://dx.doi.org/10.3390/nu2111106] [PMID: 22254000]
[39]
Petrovic S, Arsic A, Glibetic M, Cikiriz N, Jakovljevic V, Vucic V. The effects of polyphenol-rich chokeberry juice on fatty acid profiles and lipid peroxidation of active handball players: Results from a randomized, double-blind, placebo-controlled study. Can J Physiol Pharmacol 2016; 94(10): 1058-63.
[http://dx.doi.org/10.1139/cjpp-2015-0575] [PMID: 27322521]
[40]
Nowak D, Gośliński M, Szwengiel A. Multidimensional comparative analysis of phenolic compounds in organic juices with high antioxidant capacity. J Sci Food Agric 2017; 97(8): 2657-63.
[http://dx.doi.org/10.1002/jsfa.8089] [PMID: 27739084]
[41]
Arun KB, Jayamurthy P, Anusha CV, Mahesh SK, Nisha P. Fractionation of pomegranate peel studies on activity guided extracts on antidiabetic and cardiovascular protection properties. J Food Process Press 2017; 41(1)e13108https://onlinelibrary.wiley.com/doi/abs/10.1111/jfpp.13108
[42]
Orak HH, Yagar H, Isbilir SS. Comparison of antioxidant activities of juice, peel, and seed of pomegranate (Punica granatum L.) and inter-relationships with total phenolic, Tannin, anthocyanin, and flavonoid contents. Food Sci Biotechnol Internet 2012; 21(2): 373-87.
[http://dx.doi.org/10.1007/s10068-012-0049-6]
[43]
Abid M, Yaich H, Cheikhrouhou S, et al. Antioxidant properties and phenolic profile characterization by LC-MS/MS of selected Tunisian pomegranate peels. J Food Sci Technol 2017; 54(9): 2890-901.
[http://dx.doi.org/10.1007/s13197-017-2727-0] [PMID: 28928529]
[44]
Orgil O, Schwartz E, Baruch L, Matityahu I, Mahajna J, Amir R. The antioxidative and anti-proliferative potential of non-edible organs of the pomegranate fruit and tree. Lebensm Wiss Technol 2014; 58(2): 571-7.
[http://dx.doi.org/10.1016/j.lwt.2014.03.030]
[45]
Doostan F, Vafafar R, Zakeri-Milani P, Pouri A, Amini Afshar R, Mesgari Abbasi M. Effects of Pomegranate (Punica Granatum L.) Seed and Peel Methanolic Extracts on Oxidative Stress and Lipid Profile Changes Induced by Methotrexate in Rats. Adv Pharm Bull 2017; 7(2): 269-74.
[http://dx.doi.org/10.15171/apb.2017.032] [PMID: 28761829]
[46]
Vucic V. The role of dietary polyunsaturated fatty acids in inflammation. Serb J Exp Clin Res 2013; 14: 93-9.
[http://dx.doi.org/10.5937/sjecr14-4774]
[47]
Kaplan JL, Walker WA. Early gut colonization and subsequent obesity risk. Curr Opin Clin Nutr Metab Care 2012; 15(3): 278-84.
[http://dx.doi.org/10.1097/MCO.0b013e32835133cb] [PMID: 22327336]
[48]
Aziz Q, Doré J, Emmanuel A, Guarner F, Quigley EMM. Gut microbiota and gastrointestinal health: Current concepts and future directions. Neurogastroenterol Motil 2013; 25(1): 4-15.
[http://dx.doi.org/10.1111/nmo.12046] [PMID: 23279728]
[49]
Leone V, Chang EB, Devkota S. Diet, microbes, and host genetics: The perfect storm in inflammatory bowel diseases. J Gastroenterol 2013; 48(3): 315-21.
[http://dx.doi.org/10.1007/s00535-013-0777-2] [PMID: 23475322]
[50]
Borre YE, O’Keeffe GW, Clarke G, Stanton C, Dinan TG, Cryan JF. Microbiota and neurodevelopmental windows: Implications for brain disorders. Trends Mol Med 2014; 20(9): 509-18.
[http://dx.doi.org/10.1016/j.molmed.2014.05.002] [PMID: 24956966]
[51]
Fung TC, Olson CA, Hsiao EY. Interactions between the microbiota, immune and nervous systems in health and disease. Nat Neurosci 2017; 20(2): 145-55.
[http://dx.doi.org/10.1038/nn.4476] [PMID: 28092661]
[52]
Viladomiu M, Hontecillas R, Lu P, Bassaganya-Riera J. Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents. Evid Based Complement Alternat Med 2013; 2013789764
[http://dx.doi.org/10.1155/2013/789764] [PMID: 23737845]
[53]
Tan J, McKenzie C, Potamitis M, Thorburn AN, Mackay CR, Macia L. The role of short-chain fatty acids in health and disease. Adv Immunol 2014; 121: 91-119.
[http://dx.doi.org/10.1016/B978-0-12-800100-4.00003-9] [PMID: 24388214]
[54]
Huang W, Guo H-L, Deng X, et al. Short-Chain Fatty Acids Inhibit Oxidative Stress and Inflammation in Mesangial Cells Induced by High Glucose and Lipopolysaccharide. Exp Clin Endocrinol Diabetes 2017; 125(2): 98-105.
[http://dx.doi.org/10.1055/s-0042-121493] [PMID: 28049222]
[55]
den Besten G, Bleeker A, Gerding A, et al. Short-Chain Fatty Acids Protect Against High-Fat Diet-Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation. Diabetes 2015; 64(7): 2398-408.
[http://dx.doi.org/10.2337/db14-1213] [PMID: 25695945]
[56]
Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP. The continuing epidemics of obesity and diabetes in the United States. JAMA 2001; 286(10): 1195-200.
[http://dx.doi.org/10.1001/jama.286.10.1195] [PMID: 11559264]
[57]
Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: Nuclear control of metabolism. Endocr Rev 1999; 20(5): 649-88.
[PMID: 10529898]
[58]
Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 1998; 391(6662): 79-82.
[http://dx.doi.org/10.1038/34178] [PMID: 9422508]
[59]
Larrosa M, González-Sarrías A, Yáñez-Gascón MJ, et al. Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism. J Nutr Biochem 2010; 21(8): 717-25.
[http://dx.doi.org/10.1016/j.jnutbio.2009.04.012] [PMID: 19616930]
[60]
Kim H, Banerjee N, Ivanov I, et al. Comparison of anti-inflammatory mechanisms of mango (Mangifera indica L.) and pomegranate (Punica granatum L.) in a preclinical model of colitis. Mol Nutr Food Res 2016; 60(9): 1912-23.
[http://dx.doi.org/10.1002/mnfr.201501008] [PMID: 27028006]
[61]
Marín M, María Giner R, Ríos J-L, Recio MC. Intestinal anti-inflammatory activity of ellagic acid in the acute and chronic dextrane sulfate sodium models of mice colitis. J Ethnopharmacol 2013; 150(3): 925-34.
[http://dx.doi.org/10.1016/j.jep.2013.09.030] [PMID: 24140585]
[62]
Rosillo MA, Sánchez-Hidalgo M, Cárdeno A, et al. Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats. Pharmacol Res 2012; 66(3): 235-42.
[http://dx.doi.org/10.1016/j.phrs.2012.05.006] [PMID: 22677088]
[63]
Rosillo MA, Sanchez-Hidalgo M, Cárdeno A, de la Lastra CA. Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn’s disease. Biochem Pharmacol 2011; 82(7): 737-45.
[http://dx.doi.org/10.1016/j.bcp.2011.06.043] [PMID: 21763290]
[64]
Shah TA, Parikh M, Patel KV, Patel KG, Joshi CG, Gandhi TR. Evaluation of the effect of Punica granatum juice and punicalagin on NFκB modulation in inflammatory bowel disease. Mol Cell Biochem 2016; 419(1-2): 65-74.
[http://dx.doi.org/10.1007/s11010-016-2750-x] [PMID: 27352379]
[65]
Sheu ML, Chao KF, Sung YJ, Lin WW, Lin-Shiau SY, Liu SH. Activation of phosphoinositide 3-kinase in response to inflammation and nitric oxide leads to the up-regulation of cyclooxygenase-2 expression and subsequent cell proliferation in mesangial cells. Cell Signal 2005; 17(8): 975-84.
[http://dx.doi.org/10.1016/j.cellsig.2004.11.015] [PMID: 15894170]
[66]
Daynes RA, Jones DC. Emerging roles of PPARs in inflammation and immunity. Nat Rev Immunol 2002; 2(10): 748-59.
[http://dx.doi.org/10.1038/nri912] [PMID: 12360213]
[67]
Hontecillas R, O’Shea M, Einerhand A, Diguardo M, Bassaganya-Riera J. Activation of PPAR gamma and alpha by punicic acid ameliorates glucose tolerance and suppresses obesity-related inflammation. J Am Coll Nutr 2009; 28(2): 184-95.
[http://dx.doi.org/10.1080/07315724.2009.10719770] [PMID: 19828904]
[68]
Kamali M, Tavakoli H, Khodadoost M, et al. Efficacy of the Punica granatum peels aqueous extract for symptom management in ulcerative colitis patients. A randomized, placebo-controlled, clinical trial. Complement Ther Clin Pract 2015; 21(3): 141-6.
[http://dx.doi.org/10.1016/j.ctcp.2015.03.001] [PMID: 26256131]
[69]
Shukla M, Gupta K, Rasheed Z, Khan KA, Haqqi TM. Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis. Nutrition 2008; 24(7-8): 733-43.
[http://dx.doi.org/10.1016/j.nut.2008.03.013] [PMID: 18490140]
[70]
Vasiljevic D, Veselinovic M, Jovanovic M, et al. Evaluation of the effects of different supplementation on oxidative status in patients with rheumatoid arthritis. Clin Rheumatol 2016; 35(8): 1909-15.
[http://dx.doi.org/10.1007/s10067-016-3168-2] [PMID: 26758438]
[71]
Veselinovic M, Vasiljevic D, Vucic V, et al. Clinical benefits of n-3 PUFA and γ-linolenic acid in patients with rheumatoid arthritis. Nutrients 2017; 9(4)E325
[http://dx.doi.org/10.3390/nu9040325] [PMID: 28346333]
[72]
Oliviero F, Scanu A, Zamudio-Cuevas Y, Punzi L, Spinella P. Anti-inflammatory effects of polyphenols in arthritis. J Sci Food Agric 2018; 98(5): 1653-9.
[http://dx.doi.org/10.1002/jsfa.8664] [PMID: 28886220]
[73]
Ghavipour M, Sotoudeh G, Tavakoli E, Mowla K, Hasanzadeh J, Mazloom Z. Pomegranate extract alleviates disease activity and some blood biomarkers of inflammation and oxidative stress in Rheumatoid Arthritis patients. Eur J Clin Nutr 2017; 71(1): 92-6.
[http://dx.doi.org/10.1038/ejcn.2016.151] [PMID: 27577177]
[74]
de Nigris F, Balestrieri ML, Williams-Ignarro S, et al. The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats. Nitric Oxide 2007; 17(1): 50-4.
[http://dx.doi.org/10.1016/j.niox.2007.04.005] [PMID: 17553710]
[75]
Napoli C, Ignarro LJ. Nitric oxide and atherosclerosis. Nitric Oxide 2001; 5(2): 88-97.
[http://dx.doi.org/10.1006/niox.2001.0337] [PMID: 11292358]
[76]
Ignarro LJ, Byrns RE, Sumi D, de Nigris F, Napoli C. Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide. Nitric Oxide 2006; 15(2): 93-102.
[http://dx.doi.org/10.1016/j.niox.2006.03.001] [PMID: 16626982]
[77]
Betanzos-Cabrera G, Guerrero-Solano JA, Martínez-Pérez MM, Calderón-Ramos ZG, Belefant-Miller H, Cancino-Diaz J. Pomegranate juice increases levels of paraoxonase1 (PON1) expression and enzymatic activity in streptozotocin-induced diabetic mice fed with a high-fat diet. Food Res Int 2011; 44: 1381-5.
[http://dx.doi.org/10.1016/j.foodres.2011.01.042]
[78]
Taheri Rouhi SZ, Sarker MMR, Rahmat A, Alkahtani SA, Othman F. The effect of pomegranate fresh juice versus pomegranate seed powder on metabolic indices, lipid profile, inflammatory biomarkers, and the histopathology of pancreatic islets of Langerhans in streptozotocin-nicotinamide induced type 2 diabetic Sprague-Dawley rats. BMC Complement Altern Med 2017; 17(1): 156.
[http://dx.doi.org/10.1186/s12906-017-1667-6] [PMID: 28288617]
[79]
Panchal SK, Ward L, Brown L. Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. Eur J Nutr 2013; 52(2): 559-68.
[http://dx.doi.org/10.1007/s00394-012-0358-9] [PMID: 22538930]
[80]
Dushkin M, Khrapova M, Kovshik G, et al. Effects of rhaponticum carthamoides versus Glycyrrhiza glabra and Punica granatum extracts on metabolic syndrome signs in rats. BMC Complement Altern Med 2014; 14: 33.
[http://dx.doi.org/10.1186/1472-6882-14-33] [PMID: 24444255]
[81]
Noori M, Jafari B, Hekmatdoost A. Pomegranate juice prevents development of non-alcoholic fatty liver disease in rats by attenuating oxidative stress and inflammation. J Sci Food Agric 2017; 97(8): 2327-32.
[http://dx.doi.org/10.1002/jsfa.8042] [PMID: 27717115]
[82]
Dos Santos RL, Dellacqua LO, Delgado NTB, et al. Pomegranate peel extract attenuates oxidative stress by decreasing coronary angiotensin-converting enzyme (ACE) activity in hypertensive female rats. J Toxicol Environ Health A 2016; 79(21): 998-1007.
[http://dx.doi.org/10.1080/15287394.2016.1213690] [PMID: 27710705]
[83]
Delgado NTB, Rouver WD, Freitas-Lima LC, et al. Pomegranate Extract Enhances Endothelium-Dependent Coronary Relaxation in Isolated Perfused Hearts from Spontaneously Hypertensive Ovariectomized Rats. Front Pharmacol 2017; 7: 522.
[http://dx.doi.org/10.3389/fphar.2016.00522] [PMID: 28101057]
[84]
Middha SK, Usha T, Pande V. Pomegranate peel attenuates hyperglycemic effects of alloxan-induced diabetic rats. EXCLI J 2014; 13(13): 223-4.
[PMID: 26417256]
[85]
Parmar HS, Kar A. Antidiabetic potential of Citrus sinensis and Punica granatum peel extracts in alloxan treated male mice. Biofactors 2007; 31(1): 17-24.
[http://dx.doi.org/10.1002/biof.5520310102] [PMID: 18806305]
[86]
Esmaillzadeh A, Tahbaz F, Gaieni I, Alavi-Majd H, Azadbakht L. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food 2004; 7(3): 305-8.
[http://dx.doi.org/10.1089/jmf.2004.7.305] [PMID: 15383223]
[87]
Rosenblat M, Hayek T, Aviram M. Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis 2006; 187(2): 363-71.
[http://dx.doi.org/10.1016/j.atherosclerosis.2005.09.006] [PMID: 16226266]
[88]
Kerimi A, Nyambe-Silavwe H, Gauer JS, Tomás-Barberán FA, Williamson G. Pomegranate juice, but not an extract, confers a lower glycemic response on a high-glycemic index food: Randomized, crossover, controlled trials in healthy subjects. Am J Clin Nutr 2017; 106(6): 1384-93.
[http://dx.doi.org/10.3945/ajcn.117.161968] [PMID: 29021286]
[89]
Barathikannan K, Venkatadri B, Khusro A, et al. Chemical analysis of Punica granatum fruit peel and its in vitro and in vivo biological properties. BMC Complement Altern Med 2016; 16: 264.
[http://dx.doi.org/10.1186/s12906-016-1237-3] [PMID: 27476116]
[90]
Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004; 23(3): 423-33.
[http://dx.doi.org/10.1016/j.clnu.2003.10.002] [PMID: 15158307]
[91]
Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001; 158(1): 195-8.
[http://dx.doi.org/10.1016/S0021-9150(01)00412-9] [PMID: 11500191]
[92]
Moazzen H, Alizadeh M. Effects of Pomegranate Juice on Cardiovascular Risk Factors in Patients with Metabolic Syndrome: A Double-Blinded, Randomized Crossover Controlled Trial. Plant Foods Hum Nutr 2017; 72(2): 126-33.
[http://dx.doi.org/10.1007/s11130-017-0605-6] [PMID: 28303364]
[93]
Kojadinovic MI, Arsic AC, Debeljak-Martacic JD, et al. Consumption of pomegranate juice decreases blood lipid peroxidation and levels of arachidonic acid in women with metabolic syndrome. J Sci Food Agric 2017; 97(6): 1798-804.
[http://dx.doi.org/10.1002/jsfa.7977] [PMID: 27476699]
[94]
Sahebkar A, Ferri C, Giorgini P, Bo S, Nachtigal P, Grassi D. Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 2017; 115: 149-61.
[http://dx.doi.org/10.1016/j.phrs.2016.11.018] [PMID: 27888156]
[95]
Sumner MD, Elliott-Eller M, Weidner G, et al. Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease. Am J Cardiol 2005; 96(6): 810-4.
[http://dx.doi.org/10.1016/j.amjcard.2005.05.026] [PMID: 16169367]
[96]
Razani Z, Dastani M, Kazerani HR. Cardioprotective effects of Pomegranate (Punica granatum) juice in patients with ischemic heart disease. Phytother Res 2017; 31(11): 1731-8.
[http://dx.doi.org/10.1002/ptr.5901] [PMID: 28913846]
[97]
Bassiri-Jahromi S. Punica granatum (Pomegranate) activity in health promotion and cancer prevention. Oncol Rev 2018; 12(1): 345.
[http://dx.doi.org/10.4081/oncol.2018.345] [PMID: 29441150]
[98]
Kim ND, Mehta R, Yu W, et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat 2002; 71(3): 203-17.
[http://dx.doi.org/10.1023/A:1014405730585] [PMID: 12002340]
[99]
Adams LS, Zhang Y, Seeram NP, Heber D, Chen S. Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prev Res (Phila) 2010; 3(1): 108-13.
[http://dx.doi.org/10.1158/1940-6207.CAPR-08-0225] [PMID: 20051378]
[100]
Hong MY, Seeram NP, Heber D. Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor. J Nutr Biochem 2008; 19(12): 848-55.
[http://dx.doi.org/10.1016/j.jnutbio.2007.11.006] [PMID: 18479901]
[101]
Zahin M, Ahmad I, Gupta RC, Aqil F. Punicalagin and ellagic acid demonstrate antimutagenic activity and inhibition of benzo[a]pyrene induced DNA adducts. BioMed Res Int 2014; 2014467465
[http://dx.doi.org/10.1155/2014/467465] [PMID: 24949451]
[102]
Modaeinama S, Abasi M, Abbasi MM, Jahanban-Esfahlan R. Anti Tumoral Properties of Punica Granatum (Pomegranate) Peel Extract on Different Human Cancer Cells. Asian Pac J Cancer Prev 2015; 16(14): 5697-701.
[http://dx.doi.org/10.7314/APJCP.2015.16.14.5697] [PMID: 26320438]
[103]
Li Y, Yang F, Zheng W, et al. Punica granatum (pomegranate) leaves extract induces apoptosis through mitochondrial intrinsic pathway and inhibits migration and invasion in non-small cell lung cancer in vitro. Biomed Pharmacother 2016; 80: 227-35.
[http://dx.doi.org/10.1016/j.biopha.2016.03.023] [PMID: 27133061]
[104]
Seeram NP, Adams LS, Henning SM, et al. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem 2005; 16(6): 360-7.
[http://dx.doi.org/10.1016/j.jnutbio.2005.01.006] [PMID: 15936648]
[105]
Adams LS, Seeram NP, Aggarwal BB, Takada Y, Sand D, Heber D. Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agric Food Chem 2006; 54(3): 980-5.
[http://dx.doi.org/10.1021/jf052005r] [PMID: 16448212]
[106]
Larrosa M, Tomás-Barberán FA, Espín JC. The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway. J Nutr Biochem 2006; 17(9): 611-25.
[http://dx.doi.org/10.1016/j.jnutbio.2005.09.004] [PMID: 16426830]
[107]
Kojadinovic M, Arsic A, Petovic-Oggiano G, Gavrovic-Jankulovic M, Glibetic M, Popovic M. Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2. Int J Food Sci Nutr 2017; 68(8): 952-9.
[http://dx.doi.org/10.1080/09637486.2017.1328665] [PMID: 28535698]
[108]
Nuñez-Sánchez MA, García-Villalba R, Monedero-Saiz T, et al. Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients. Mol Nutr Food Res 2014; 58(6): 1199-211.
[http://dx.doi.org/10.1002/mnfr.201300931] [PMID: 24532260]
[109]
Adhami VM, Khan N, Mukhtar H. Cancer chemoprevention by pomegranate: Laboratory and clinical evidence. Nutr Cancer 2009; 61(6): 811-5.
[http://dx.doi.org/10.1080/01635580903285064] [PMID: 20155621]
[110]
Ahmadiankia N, Bagheri M, Fazli M. Gene Expression Changes in Pomegranate Peel Extract-Treated Triple-Negative Breast Cancer Cells. Rep Biochem Mol Biol 2018; 7(1): 102-9.
[PMID: 30324124]
[111]
Mandal A, Bhatia D, Bishayee A. Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-κB and Nrf2 Signaling Pathways. Nutrients 2017; 9(5)E436
[http://dx.doi.org/10.3390/nu9050436] [PMID: 28452959]
[112]
Bishayee A, Mandal A, Bhattacharyya P, Bhatia D. Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis. Nutr Cancer 2016; 68(1): 120-30.
[http://dx.doi.org/10.1080/01635581.2016.1115094] [PMID: 26699876]
[113]
Mandal A, Bishayee A. Mechanism of Breast Cancer Preventive Action of Pomegranate: Disruption of Estrogen Receptor and Wnt/β-Catenin Signaling Pathways. Molecules 2015; 20(12): 22315-28.
[http://dx.doi.org/10.3390/molecules201219853] [PMID: 26703530]
[114]
Husari A, Khayat A, Bitar H, et al. Antioxidant activity of pomegranate juice reduces acute lung injury secondary to hyperoxia in an animal model. BMC Res Notes 2014; 7: 664.
[http://dx.doi.org/10.1186/1756-0500-7-664] [PMID: 25241213]
[115]
Pantuck AJ, Leppert JT, Zomorodian N, et al. Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clin Cancer Res 2006; 12(13): 4018-26.
[http://dx.doi.org/10.1158/1078-0432.CCR-05-2290] [PMID: 16818701]
[116]
Paller CJ, Pantuck A, Carducci MA. A review of pomegranate in prostate cancer. Prostate Cancer Prostatic Dis 2017; 20(3): 265-70.
[http://dx.doi.org/10.1038/pcan.2017.19] [PMID: 28440320]
[117]
Stenner-Liewen F, Liewen H, Cathomas R, et al. Daily Pomegranate Intake Has No Impact on PSA Levels in Patients with Advanced Prostate Cancer - Results of a Phase IIb Randomized Controlled Trial. J Cancer 2013; 4(7): 597-605.
[http://dx.doi.org/10.7150/jca.7123] [PMID: 24069070]

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