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Current Protein & Peptide Science


ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Review Article

Allergen-like Molecules from Parasites

Author(s): Ju Yeong Kim, Myung-Hee Yi and Tai-Soon Yong*

Volume 21, Issue 2, 2020

Page: [186 - 202] Pages: 17

DOI: 10.2174/1389203720666190708154300

Price: $65


Parasite infections modulate immunologic responses, and the loss of parasite infections in the last two to three decades might explain the increased prevalence of allergic diseases in developed countries. However, parasites can enhance allergic responses. Parasites contain or release allergen-like molecules that induce the specific immunoglobulin, IgE, and trigger type-2 immune responses. Some parasites and their proteins, such as Anisakis and Echinococcus granulosus allergens, act as typical allergens. A number of IgE-binding proteins of various helminthic parasites are cross-reactive to other environmental allergens, which cause allergic symptoms or hamper accurate diagnosis of allergic diseases. The cross-reactivity is based on the fact that parasite proteins are structurally homologous to common environmental allergens. In addition, IgE-binding proteins of parasites might be useful for developing vaccines to prevent host re-infection. This review discusses the functions of the IgE-biding proteins of parasites.

Keywords: Allergen, Anisakis, Echinococcus granulosus, IgE-binding protein, parasite, helminths.

Graphical Abstract
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