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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Review Article

Advances in the Chemistry of 6-6 Bicyclic Systems: Chemistry of Pyrido[3,4- d]pyrimidines

Author(s): Mohamed Monier, Doaa Abdel-Latif, Ahmed El-Mekabaty, Başak D. Mert and Khaled M. Elattar*

Volume 16, Issue 6, 2019

Page: [812 - 854] Pages: 43

DOI: 10.2174/1570179416666190704113647

Price: $65


The aim of this work is to discuss the chemistry of pyrido[3,4-d]pyrimidines as one of the most important heterocyclic compounds with remarkable synthetic, biological and medical applications. In this overview, the chemistry of heterocyclic compounds incorporated the pyrido[3,4-d]pyrimidine scaffold as demonstrated by chemical reactions and different preparation processes. The anticipated compounds were synthesized from pyridine or pyrimidine compounds and a description of the reactivity of substituents attached to ring carbon and nitrogen atoms is discussed. On the other hand, the synthesis and reactions of fused heterocycles incorporated pyrido[3,4-d]pyrimidine scaffold is described. The diamine analogs included pyrido[3,4-d]pyrimidine core were reported as tyrosine kinase inhibitors. The chemical reactions of certain unexpected and chemically substantial compounds have been discussed.

Keywords: Pyrido[3, 4-d]pyrimidines, substituents’ reactivity, synthetic routes, biological applications, heterocyclic compounds, tyrosine kinase inhibitors.

Graphical Abstract
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