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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Review Article

1,4-Diazepines: A Review on Synthesis, Reactions and Biological Significance

Author(s): Muhammad A. Rashid, Aisha Ashraf*, Sahibzada S. Rehman, Shaukat A. Shahid, Adeel Mahmood and Muhammad Faruq

Volume 16, Issue 5, 2019

Page: [709 - 729] Pages: 21

DOI: 10.2174/1570179416666190703113807

Price: $65


Background: 1,4-Diazepines are two nitrogen containing seven membered heterocyclic compounds and associated with a wide range of biological activities. Due to its medicinal importance, scientists are actively involved in the synthesis, reactions and biological evaluation of 1,4-diazepines since number of decades.

Objective: The primary purpose of this review is to discuss the synthetic schemes and reactivity of 1,4- diazepines. This article also describes biological aspects of 1,4-diazepine derivatives, that can be usefully exploited for the pharmaceutical sector.

Conclusion: This review summarizes the abundant literature on synthetic routes, chemical reactions and biological attributes of 1,4-diazepine derivatives. We concluded that 1,4-diazepines have significant importance due to their biological activities like antipsychotic, anxiolytic, anthelmintic, anticonvulsant, antibacterial, antifungal and anticancer. 1,4-diazepine derivatives with significant biological activities could be explored for potential use in the pharmaceutical industries.

Keywords: 1, 4-Diazepines, synthesis, reactions, biological activities, heterocyclic compounds, biological activities.

Graphical Abstract
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