Introduction: In continuation of our efforts to find new antimicrobials, herein we report the synthesis of various pyrazole, pyrazoline, and pyridine based novel bioactive heterocycles (3a-t).
Methods: Newly synthesized compounds were analysed for their antimicrobial activity. Compounds 3c, 3h, 3i, 3k, 3n, and 3q showed significant antimicrobial activity.
Results: Molecular docking study for the most active analogues against DNA gyrase subunit b (PDB ID: 1KZN) corroborated well with the observed antimicrobial potency exhibiting significant binding affinity.
Conslusion: Interpretation of the chemical structures reported in this paper was based on IR, 1H NMR, 13C NMR, and mass spectral data.
[http://dx.doi.org/10.1016/j.ejmech.2014.10.079] [PMID: 25462270]
[http://dx.doi.org/10.1016/j.ejmech.2013.12.001] [PMID: 24384550]
[http://dx.doi.org/10.1051/vetres:2000100] [PMID: 10958240]
[http://dx.doi.org/10.1021/jm051256o] [PMID: 17034125]
[http://dx.doi.org/10.1021/jm0306430] [PMID: 15027865]