Background: Angiogenesis is tightly linked to inflammation. Cytokines of interleukin 1 (IL-1) family are key mediators in modulating inflammatory responses.
Methods: In this study, we examined the role of IL-38, a member of the IL-1 family, in mediating inflammation-induced angiogenesis.
Results: The results showed that the angiogenesis was attenuated by topical administration of IL-38 to the injured corneas in a mouse model of alkali-induced corneal neovascularization (CNV). Further study showed that the expression of inflammatory cytokines TNF-α, IL-6, IL-8 and IL-1β was decreased in the IL-38-treated corneas. Moreover, the angiogenic activities including the proliferation, migration and tube formation of human retinal endothelial cells were reduced by IL-38 treatment in vitro.
Conclusion: The data indicate that IL-38 modulates inflammation-induced angiogenesis.
[http://dx.doi.org/10.1097/00003226-198706040-00004] [PMID: 2446823]
[http://dx.doi.org/10.1146/annurev-cellbio-092910-154002] [PMID: 21756109]
[http://dx.doi.org/10.1161/CIRCULATIONAHA.110.948570] [PMID: 21300955]
[http://dx.doi.org/10.1111/j.1744-313X.2009.00889.x] [PMID: 19930406]