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Current Women`s Health Reviews


ISSN (Print): 1573-4048
ISSN (Online): 1875-6581

Research Article

Comparative Studies on Hormonal Changes and Metabolic Syndrome in Perimenopausal and Premenopausal Igbo Women in Enugu Metropolis Nigeria: A Cross-sectional Study

Author(s): Chinwe Ifeoma Ikegwuonu, Uchendu Kingsley Ikenna*, Okonkwo Innocent Nwabueze, Mba Chika Betina, Maduka Ignatius Chukwudi and Onyenekwe Charles Chinedum

Volume 15, Issue 4, 2019

Page: [284 - 294] Pages: 11

DOI: 10.2174/1381612825666190618125726

Price: $65


Background and Objective: Few studies have focused on the epidemiology of perimenopausal syndrome, and its prevalence in African women is concerningly high. This study investigated selected biochemical parameters, hormonal changes, and possible metabolic syndrome (MetS) in perimenopausal and premenopausal women among Igbo women in Enugu, Southeast of Nigeria.

Methods: This study was conducted between March 2018 and November 2018. A total of 200 apparently healthy women, comprising 120 perimenopausal women (mean age 50 years) and 80 premenopausal women (mean age 35 years), living in Enugu, were randomly recruited for this study. Anthropometric indices (blood pressure, waist circumference, weight, and height) of these women were measured. Fasting blood samples were collected and used for measurement of luteinizing hormone (LH), estradiol (E2), follicle stimulating hormone (FSH), fasting plasma glucose (FPG), and lipid profile using standard methods. MetS in the perimenopausal and premenopausal women was observed using three different criteria: the National Cholesterol Education Program- Adult Treatment Panel 111 (NCEP-ATP 111), the World Health Organization (WHO), and International Diabetes Federation (IDF). Student’s t-test and Chi-square were used to compare continuous and categorical variables.

Results: There were significantly (p<0.05) higher values of blood pressure (systolic and diastolic), FPG, waist circumference, LH, FSH, total cholesterol, and LDL-C, but significantly (p<0.05) lower values of estradiol in perimenopausal women as compared to premenopausal women. The incidence of MetS was higher in perimenopausal women as compared to premenopausal women in all the three criteria studied.

Interpretation and Conclusion: Perimenopausal women have a higher risk for the development of metabolic syndrome-associated diseases than premenopausal women.

Keywords: Perimenopause, premenopause, biochemical changes, metabolic syndrome, Igbo women, Nigeria.

Graphical Abstract
Adeoye AM, Adewoye IA, Dairo DM, et al. Excess metabolic syndrome risks among women health workers compared with men. J Clin Hypertens (Greenwich) 2015; 17(11): 880-4.
Carr MC. The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab 2003; 88(6): 2404-11.
Wahab KW, Sani M, Gbadamosi M, Yandutse M. Frequency and determinants of the metabolic syndrome in apparently healthy Nigerians. Trop Doct 2008; 38: 224-6.
Albert KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus, and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15: 539-53.
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA 2001; 285(19): 2486-97.
Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/ National Heart, Lung and Blood Institute Scientific Statement. Circulation 2005; 112(17): 2735-52.
Zimmet P, Magliano D, Matsuzawa Y, et al. The metabolic syndrome: A global public health problem and a new definition. J Atheroscler Thromb 2005; 12: 295-300.
Achie LA, Olorunshola KV, Toryila JE, Tende JA. The body mass index, waist circumference and blood pressure of postmenopausal Women in Zaria, Northern Nigeria. Curr Res J Biol Sci 2012; 4(3): 329-32.
Harlow SD, Gass M, Hall JE, et al. Executive summary of the Stages of Reproductive Aging Workshop + 10: Addressing the unfinished agenda of staging reproductive aging. J Clin Endocrinol Metab 2012; 97(4): 1159-68.
Manson JE, Kaunitz AM. Menopause management: Getting clinical care back on track. N Engl J Med 2016; 374(9): 803-6.
Dienye PO, Judah F, Ndukwu G. Frequency of symptoms and health seeking behaviours of menopausal women in an out-patient clinic in Port Harcourt, Nigeria. Glob J Health Sci 2013; 5(4): 39-47.
Ameh N, Madugu NH, Onwusulu D, Eleje G, Oyefabi A. Prevalence and predictors of menopausal symptoms among postmenopausal Ibo and Hausa women in Nigeria. Trop J Obstet Gynaecol 2016; 33(3): 263-9.
Oguoma VM, Nwose EU, Ulasi II, et al. Cardiovascular disease risk factors in a Nigerian population with impaired fasting blood glucose level and diabetes mellitus. BMC Public Health 2017; 17(36): 3910-3.
Hu G, Qiao Q, Tumilehto J, et al. Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in non-diabetic European men and women. Arch Intern Med 2004; 164: 1066-76.
Tietz NW. Clinical Guide to Laboratory Tests. 3rd edition. W. B. Saunders, co Philadelphia 1995; pp. 216-7.
Uotila M, Ruoslaliti E, Engvall E. Two-site sandwich enzyme immunoassay with monoclonal antibody to human alpha-fetoprotein. J Immunol Methods 1981; 42(1): 11-5.
Fossati P, Prencipe L. Serum triglycerides determined colourimetrically with an enzyme that produces hydrogen peroxide. Clin Chem 1982; 28: 2077-80.
Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem 1974; 20: 470-5.
Burstein M, Scholnick HR, Morfin R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res 1970; 11(6): 583-95.
Bachorik PS. Measurement of low density lipoprotein cholesterol. In: Rifai N, Warnick GR, Dominiczak MH, (eds.). Handbook of Lipoprotein Testing. AACC Press: Washington DC, 1997; pp. 145-60.
Friedewald WT, Levy RL, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
International Diabetes Federation (IDF). The IDF Consensus worldwide definition of the metabolic syndrome. Available from. http: // docs/IDF Metabolic syndrome definition, 2005, [Accessed on: June 15, 2018].
Williams MR, Westerman RA, Kingwell BA. Variations in endothelial function and arterial compliance during the menstrual cycle. J Clin Endocrinol Metab 2001; 86: 5389-95.
Bechlioulis A, Naka KK, Papanikolau O, Kontostolis E, Kalantaridou SN, Michalis LK. Menopause and hormone therapy: From vascular endothelial function to cardiovascular disease. Hellenic J Cardiol 2009; 50: 303-15.
Fareed-KowNanse A, Adu-Frimpong M, Osei-Yeboah J, Mensah FO, Owusu L. The prevalence of metabolic syndrome and its predominant components among pre-and postmenopausal Ghanaian women. BMC Res Notes 2013; 6: 446.
Marti CN, Gheorghiade M, Kalogeropoulos AP, Georgiopoulou VV, Quyyumi AA, Butler J. Endothelial dysfunction, Arterial stiffness and heart failure. J Am Coll Cardiol 2012; 60(16): 1455-69.
Saladin KS. Anatomy and Physiology. 6th edition. McGraw – Hill New York 2012; pp. 1075-7.
Usoro CAO, Adikwuru CC, Usoro IN, Nsonwu AC. Lipid profile of postmenopausal women in Calabar, Nigeria. Pak J Nutr 2006; 5: 79-82.
Tomiyama H, Matsumoto C, Yamada J, et al. Predictors of progression from prehypertension to hypertension in Japanese men. Am J Hypertens 2009; 22(6): 630-6.
Samat A, Rahim A, Barnett A. Pharmacotherapy for obesity in menopausal women. Menopause Int 2008; 14: 57-62.
Maltais ML, Desroches J, Dionne IJ. Changes in muscles mass and strength after menopause. J Musculoskelet Neuronal Interact 2009; 9(4): 186-97.
Donato GB, Giovana B, Fuchs SC, Bastos C, Spritzer PM. Association between menopause status and central adiposity measured at different cutoffs of waist circumference and waist-to-hip ratio. Menopause 2006; 13(2): 280-5.
Crawford S, Casey VA, Avis N, McKinlay SM. A longitudinal study of weight and the menopause transition: Results from the Massachusetts women’s health study. Menopause 2000; 7(2): 96-104.
Pischon T, Boeing H, Hoffinann K. General and abdominal adiposity and risk of death in Europe. N Engl J Med 2008; 359(20): 2015-20.
Dudeja VA, Misra RM, Pandey GD, Devina G, Kumar G, Vikram NK. BMI does not accurately predict overweight in Asian Indians in northern India. Br J Nutr 2001; 86: 105-12.
Janssen I, Powell LH, Crawford S, Lasley B, Sutton-Tyrrell K. Menopause and the metabolic syndrome: The Study of Women’s Health Across the Nation. Arch Intern Med 2008; 168: 1568-75.
Toth MJ, Sites CK, Eltabbakh GH, Poehlman ET. Effect of menopausal status on insulin-stimulated glucose disposal: Comparison of middle-aged premenopausal and early postmenopausal women. Diabetes Care 2000; 23: 801-6.
Innocent O. ThankGod OO, Sandra EO, Josiah IE. Correlation between body mass index and blood glucose levels among some Nigerian undergraduates. HOAJ Biol 2013; 2: 4.
Casiglia E, Tikhonoff V, Sandrocaffi A, et al. Menopause does not affect blood pressure and risk profile, menopausal women do not become similar to men. J Hypertens 2008; 26: 1983-92.
Isong IK, Okhormhe ZA, Eze-Bassey I, Okpokam DC, Usoro CAO. Levels of prolactin, progesterone, estradiol, luteinizing hormone and follicle stimulating hormone in infertile women in calabar, Nigeria. IJRCOG 2016; 5(3): 1770-89.
Klasssen CL, Hines SL, Ghosh K. Common benign breast concerns for primary care physician. Cleve Clin J Med 2019; 86(1): 57-65.
Santen RJ. Benign breast disease in women In: Feingold KR, Anawalt B, Boyce A, et al (eds) EndotextMDTextcom, Inc: South Dartmouth, MA2000
Isik A, Grassi A, Soran A. Positive axilla in breast cancer; clinical practice in 2018. Eur J Breast Health 2018; 14: 134-5.
Zsarnovszky A, Kiss D, Jocsak G, Nemeth G, Toth I, Horvath TL. Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum. Front Neuroendocrinol 2018; 48: 23-36.
Isik A, Firat D, Yilmaz I, et al. A survey of current approaches to thyroid nodules and thyroid operation Int J Surg 2018; 54(Part A): 100-4.
Chen CY, Chen ST, Huang BY, Hwang JS. Lin JD1, Liu FH. The effect of suppressive thyroxine therapy in nodular goiter in postmenopausal women and 2 year’s bone mineral density change. Endocr J 2018; 65(11): 1101-9.
Berg GA, Siseles N, Gonzalez AI, Ortiz OC, Tempone A, Wikinski RW. Higher values of hepatic lipase activity in postmenopause: relationship with atherogenic intermediate density and low density lipoproteins. Menopause 2001; 8: 51-7.
Matthews KA, Kuller LH, Sutton-Tyrrell K, Chang YF. Changes in cardiovascular risk factors during the perimenopause and postmenopause and carotid artery atherosclerosis in healthy women. Stroke 2001; 32: 1104-11.
Berristein L, Ross RK. Endogenous hormones and breast cancer risk. Epidemiol Rev 1993; 15: 48-50.
Janssen I, Powell LH, Kazlauskaite R, Dugan SA. Testosterone and visceral fat in midlife women: the Study of Women’s Health Across the Nation (SWAN) fat patterning study. Obesity (Silver Spring) 2010; 18: 604-10.
Mesch V, Boero L, Siseles N, et al. Metabolic syndrome throughout the menopausal transition; Influence of age and menopausal status. Climacteric 2006; 9(1): 40-8.
Igwe JC, Nwagha IU, Okaro JM. The effects of menopause on the serum lipid profile of normal females of South East Nigeria. Niger J Physiol Sci 2005; 20(1-2): 48-53.
Zhu L, Lang J, Liu C, Han S, Huang J, Li X. The epidemiological study of women with urinary incontinence and risk factors for stress urinary incontinence in China. Menopause 2009; 16: 831-6.
Frank ATH, Zhao B, Jose PO, et al. Racial/Ethnic differences in dyslipidaemia patterns. Circulation 2014; 129(5): 570-9.
Carr MC, Kim KH, Zambon A, et al. Changes in LDL density across the menopausal transition. J Investig Med 2000; 48: 245-50.
Kalavathi L, Dhruvanarayan HR, Zachariah E. Plasma estradiol and lipid profile in perimenopausal women. Indian J Physiol Pharmacol 1991; 35(4): 260-2.
Siminialayi IM, Emem-Chioma PC, Odia OJ. Prevalence of metabolic syndrome in Urban and sub urban Rivers State, Nigeria: International Diabetes Federation and Adult Treatment Panel 111 definitions. Niger Postgrad Med J 2010; 17(2): 147-53.

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