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Infectious Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Review Article

Antiviral Drugs and Acute Kidney Injury (AKI)

Author(s): Wattana Leowattana *

Volume 19, Issue 4, 2019

Page: [375 - 382] Pages: 8

DOI: 10.2174/1871526519666190617154137

Price: $65

Abstract

The introduction of more efficient antiviral drugs are common cause drug-induced acute kidney injury (AKI). The true prevalence of antiviral drugs induced nephrotoxicity is hardly determined. It causes AKI by many mechanisms including acute tubular necrosis (ATN), allergic interstitial nephritis (AIN), and crystal nephropathy. ATN has been described with a few kinds of antiviral drugs such as cidofovir, adefovir and tenofovir with unique effects on transporter defects, apoptosis, and mitochondrial injury. AIN from atazanavir is a rapid onset of AKI and usually nonoliguric but dialytic therapy are needed because of severity. Additionally, crystal nephropathy from acyclovir, indinavir, and foscarnet can cause AKI due to intratubular obstruction. In this article, the mechanisms of antiviral drug-induced AKI were reviewed and strategies for preventing AKI were mentioned.

Keywords: Antiviral drugs, acute kidney injury (AKI), cidofovir, adefovir, tenofovir, atazanavir, acyclovir, indinavir, foscarnet.

Graphical Abstract
[1]
Bellomo, R.; Kellum, J.A.; Ronco, C. Acute kidney injury. Lancet, 2012, 380(9843), 756-766.
[http://dx.doi.org/10.1016/S0140-6736(11)61454-2] [PMID: 22617274]
[2]
Eftekhari, P. Evaluation of acute kidney injury in the hospital setting. Prim. Care, 2014, 41(4), 779-802.
[http://dx.doi.org/10.1016/j.pop.2014.08.005] [PMID: 25439534]
[3]
Mesropian, P.D.; Othersen, J.; Mason, D.; Wang, J.; Asif, A.; Mathew, R.O. Community-acquired acute kidney injury: A challenge and opportunity for primary care in kidney health. Nephrology (Carlton), 2016, 21(9), 729-735.
[http://dx.doi.org/10.1111/nep.12751] [PMID: 26890822]
[4]
Susantitaphong, P.; Cruz, D.N.; Cerda, J.; Abulfaraj, M.; Alqahtani, F.; Koulouridis, I.; Jaber, B.L. World incidence of AKI: a meta-analysis. Clin. J. Am. Soc. Nephrol., 2013, 8(9), 1482-1493.
[http://dx.doi.org/10.2215/CJN.00710113] [PMID: 23744003]
[5]
Uchino, S.; Kellum, J.A.; Bellomo, R.; Doig, G.S.; Morimatsu, H.; Morgera, S.; Schetz, M.; Tan, I.; Bouman, C.; Macedo, E.; Gibney, N.; Tolwani, A.; Ronco, C. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA, 2005, 294(7), 813-818.
[http://dx.doi.org/10.1001/jama.294.7.813] [PMID: 16106006]
[6]
Izzedine, H.; Launay-Vacher, V.; Deray, G. Antiviral drug-induced nephrotoxicity. Am. J. Kidney Dis., 2005, 45(5), 804-817.
[http://dx.doi.org/10.1053/j.ajkd.2005.02.010] [PMID: 15861345]
[7]
Perazella, M.A. Renal vulnerability to drug toxicity. Clin. J. Am. Soc. Nephrol., 2009, 4(7), 1275-1283.
[http://dx.doi.org/10.2215/CJN.02050309] [PMID: 19520747]
[8]
Lee, W.; Kim, R.B. Transporters and renal drug elimination. Annu. Rev. Pharmacol. Toxicol., 2004, 44, 137-166.
[http://dx.doi.org/10.1146/annurev.pharmtox.44.101802.121856] [PMID: 14744242]
[9]
Naesens, L.; Lenaerts, L.; Andrei, G.; Snoeck, R.; Van Beers, D.; Holy, A.; Balzarini, J.; De Clercq, E. Antiadenovirus activities of several classes of nucleoside and nucleotide analogues. Antimicrob. Agents Chemother., 2005, 49(3), 1010-1016.
[http://dx.doi.org/10.1128/AAC.49.3.1010-1016.2005] [PMID: 15728896]
[10]
Bernhoff, E.; Gutteberg, T.J.; Sandvik, K.; Hirsch, H.H.; Rinaldo, C.H. Cidofovir inhibits polyomavirus BK replication in human renal tubular cells downstream of viral early gene expression. Am. J. Transplant., 2008, 8(7), 1413-1422.
[http://dx.doi.org/10.1111/j.1600-6143.2008.02269.x] [PMID: 18510636]
[11]
Cundy, K.C.; Petty, B.G.; Flaherty, J.; Fisher, P.E.; Polis, M.A.; Wachsman, M.; Lietman, P.S.; Lalezari, J.P.; Hitchcock, M.J.; Jaffe, H.S. Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients. Antimicrob. Agents Chemother., 1995, 39(6), 1247-1252.
[http://dx.doi.org/10.1128/AAC.39.6.1247] [PMID: 7574510]
[12]
Cundy, K.C. Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir. Clin. Pharmacokinet., 1999, 36(2), 127-143.
[http://dx.doi.org/10.2165/00003088-199936020-00004] [PMID: 10092959] [http://dx.doi.org/10.2165/00003088-199936020-00004] [PMID: 10092959]
[13]
Lalezari, J.P.; Holland, G.N.; Kramer, F.; McKinley, G.F.; Kemper, C.A.; Ives, D.V.; Nelson, R.; Hardy, W.D.; Kuppermann, B.D.; Northfelt, D.W.; Youle, M.; Johnson, M.; Lewis, R.A.; Weinberg, D.V.; Simon, G.L.; Wolitz, R.A.; Ruby, A.E.; Stagg, R.J.; Jaffe, H.S. Randomized, controlled study of the safety and efficacy of intravenous cidofovir for the treatment of relapsing cytomegalovirus retinitis in patients with AIDS. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol., 1998, 17(4), 339-344.
[http://dx.doi.org/10.1097/00042560-199804010-00008] [PMID: 9525435]
[14]
Ortiz, A.; Justo, P.; Sanz, A.; Melero, R.; Caramelo, C.; Guerrero, M.F.; Strutz, F.; Müller, G.; Barat, A.; Egido, J. Tubular cell apoptosis and cidofovir-induced acute renal failure. Antivir. Ther. (Lond.), 2005, 10(1), 185-190.
[PMID: 15751777]
[15]
Meier, P.; Dautheville-Guibal, S.; Ronco, P.M.; Rossert, J. Cidofovir-induced end-stage renal failure. Nephrol. Dial. Transplant., 2002, 17(1), 148-149.
[http://dx.doi.org/10.1093/ndt/17.1.148] [PMID: 11773481]
[16]
Ho, E.S.; Lin, D.C.; Mendel, D.B.; Cihlar, T. Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1. J. Am. Soc. Nephrol., 2000, 11(3), 383-393.
[PMID: 10703662]
[17]
Segovia, M.C.; Chacra, W.; Gordon, S.C. Adefovir dipivoxil in chronic hepatitis B: history and current uses. Expert Opin. Pharmacother., 2012, 13(2), 245-254.
[http://dx.doi.org/10.1517/14656566.2012.649727] [PMID: 22242973]
[18]
Wong, G.L.; Seto, W.K.; Wong, V.W.; Yuen, M.F.; Chan, H.L. Review article: long-term safety of oral anti-viral treatment for chronic hepatitis B. Aliment. Pharmacol. Ther., 2018, 47(6), 730-737.
[http://dx.doi.org/10.1111/apt.14497] [PMID: 29359487]
[19]
Cihlar, T.; Lin, D.C.; Pritchard, J.B.; Fuller, M.D.; Mendel, D.B.; Sweet, D.H. The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol. Pharmacol., 1999, 56(3), 570-580.
[http://dx.doi.org/10.1124/mol.56.3.570] [PMID: 10462545]
[20]
Wada, S.; Tsuda, M.; Sekine, T.; Cha, S.H.; Kimura, M.; Kanai, Y.; Endou, H. Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs. J. Pharmacol. Exp. Ther., 2000, 294(3), 844-849.
[PMID: 10945832]
[21]
Tanji, N.; Tanji, K.; Kambham, N.; Markowitz, G.S.; Bell, A.; D’agati, V.D. Adefovir nephrotoxicity: possible role of mitochondrial DNA depletion. Hum. Pathol., 2001, 32(7), 734-740.
[http://dx.doi.org/10.1053/hupa.2001.25586] [PMID: 11486172]
[22]
Hadziyannis, S.J.; Tassopoulos, N.C.; Heathcote, E.J.; Chang, T.T.; Kitis, G.; Rizzetto, M.; Marcellin, P.; Lim, S.G.; Goodman, Z.; Ma, J.; Arterburn, S.; Xiong, S.; Currie, G.; Brosgart, C.L. Adefovir Dipivoxil 438 Study Group. Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B. N. Engl. J. Med., 2005, 352(26), 2673-2681.
[http://dx.doi.org/10.1056/NEJMoa042957] [PMID: 15987916]
[23]
Marcellin, P.; Gane, E.; Buti, M.; Afdhal, N.; Sievert, W.; Jacobson, I.M.; Washington, M.K.; Germanidis, G.; Flaherty, J.F.; Aguilar Schall, R.; Bornstein, J.D.; Kitrinos, K.M.; Subramanian, G.M.; McHutchison, J.G.; Heathcote, E.J. Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study. Lancet, 2013, 381(9865), 468-475.
[http://dx.doi.org/10.1016/S0140-6736(12)61425-1] [PMID: 23234725]
[24]
Kearney, B.P.; Flaherty, J.F.; Shah, J. Tenofovir disoproxil fumarate: clinical pharmacology and pharmacokinetics. Clin. Pharmacokinet., 2004, 43(9), 595-612.
[http://dx.doi.org/10.2165/00003088-200443090-00003] [PMID: 15217303]
[25]
Fernandez-Fernandez, B.; Montoya-Ferrer, A.; Sanz, A.B.; Sanchez-Niño, M.D.; Izquierdo, M.C.; Poveda, J.; Sainz-Prestel, V.; Ortiz-Martin, N.; Parra-Rodriguez, A.; Selgas, R.; Ruiz-Ortega, M.; Egido, J.; Ortiz, A. Tenofovir nephrotoxicity: 2011 update. Aids Res. Treat., 2011, 2011354908
[http://dx.doi.org/10.1155/2011/354908] [PMID: 21716719]
[26]
Wong, G.L.; Tse, Y.K.; Wong, V.W.; Yip, T.C.; Tsoi, K.K.; Chan, H.L. Long-term safety of oral nucleos(t)ide analogs for patients with chronic hepatitis B: A cohort study of 53,500 subjects. Hepatology, 2015, 62(3), 684-693.
[http://dx.doi.org/10.1002/hep.27894] [PMID: 25973979]
[27]
Ahn, J.; Lee, H.M.; Lim, J.K.; Pan, C.Q.; Nguyen, M.H.; Ray Kim, W.; Mannalithara, A.; Trinh, H.; Chu, D.; Tran, T.; Min, A.; Do, S.; Te, H.; Reddy, K.R.; Lok, A.S. Entecavir safety and effectiveness in a national cohort of treatment-naïve chronic hepatitis B patients in the US - the ENUMERATE study. Aliment. Pharmacol. Ther., 2016, 43(1), 134-144.
[http://dx.doi.org/10.1111/apt.13440] [PMID: 26510638]
[28]
Riveiro-Barciela, M.; Tabernero, D.; Calleja, J.L.; Lens, S.; Manzano, M.L.; Rodríguez, F.G.; Crespo, J.; Piqueras, B.; Pascasio, J.M.; Comas, C.; Gutierrez, M.L.; Aguirre, A.; Suárez, E.; García-Samaniego, J.; Rivero, M.; Acero, D.; Fernandez-Bermejo, M.; Moreno, D.; Sánchez-Pobre, P.; de Cuenca, B.; Moreno-Palomares, J.J.; Esteban, R.; Buti, M. Effectiveness andsafety of entecavir or tenofovir in a Spanish cohort of chronic hepatitisB patients: validation of the page-B score to predict hepatocellular carcinoma. Dig. Dis. Sci., 2017, 62(3), 784-793.
[http://dx.doi.org/10.1007/s10620-017-4448-7] [PMID: 28078526]
[29]
Raghavan, R.; Eknoyan, G. Acute interstitial nephritis - a reappraisal and update. Clin. Nephrol., 2014, 82(3), 149-162.
[http://dx.doi.org/10.5414/CN10838] [PMID: 25079860]
[30]
Praga, M.; González, E. Acute interstitial nephritis. Kidney Int., 2010, 77(11), 956-961.
[http://dx.doi.org/10.1038/ki.2010.89] [PMID: 20336051]
[31]
Croom, K.F.; Dhillon, S.; Keam, S.J. Atazanavir: a review of its use in the management of HIV-1 infection. Drugs, 2009, 69(8), 1107-1140.
[http://dx.doi.org/10.2165/00003495-200969080-00009] [PMID: 19496633]
[32]
Brewster, U.C.; Perazella, M.A. Acute interstitial nephritis associated with atazanavir, a new protease inhibitor. Am. J. Kidney Dis., 2004, 44(5), e81-e84.
[http://dx.doi.org/10.1016/S0272-6386(04)01093-5] [PMID: 15492941]
[33]
Schmid, S.; Opravil, M.; Moddel, M.; Huber, M.; Pfammatter, R.; Keusch, G.; Ambuhl, P.; Wuthrich, R.P.; Moch, H.; Varga, Z. Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy in a retrospective analysis of kidney biopsies. Virchows Arch., 2007, 450(6), 665-670.
[http://dx.doi.org/10.1007/s00428-007-0418-3] [PMID: 17464512]
[34]
Hara, M.; Suganuma, A.; Yanagisawa, N.; Imamura, A.; Hishima, T.; Ando, M. Atazanavir nephrotoxicity. Clin. Kidney J., 2015, 8(2), 137-142.
[http://dx.doi.org/10.1093/ckj/sfv015] [PMID: 25815168]
[35]
Mulay, S.R.; Anders, H.J. Crystal nephropathies: mechanisms of crystal-induced kidney injury. Nat. Rev. Nephrol., 2017, 13(4), 226-240.
[http://dx.doi.org/10.1038/nrneph.2017.10] [PMID: 28218266]
[36]
Yarlagadda, S.G.; Perazella, M.A. Drug-induced crystal nephropathy: an update. Expert Opin. Drug Saf., 2008, 7(2), 147-158.
[http://dx.doi.org/10.1517/14740338.7.2.147] [PMID: 18324877]
[37]
Wagstaff, A.J.; Faulds, D.; Goa, K.L. Aciclovir. A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Drugs, 1994, 47(1), 153-205.
[http://dx.doi.org/10.2165/00003495-199447010-00009] [PMID: 7510619]
[38]
Sawyer, M.H.; Webb, D.E.; Balow, J.E.; Straus, S.E. Acyclovir-induced renal failure. Clinical course and histology. Am. J. Med., 1988, 84(6), 1067-1071.
[http://dx.doi.org/10.1016/0002-9343(88)90313-0] [PMID: 3376977]
[39]
Bean, B.; Aeppli, D. Adverse effects of high-dose intravenous acyclovir in ambulatory patients with acute herpes zoster. J. Infect. Dis., 1985, 151(2), 362-365.
[http://dx.doi.org/10.1093/infdis/151.2.362] [PMID: 3881542]
[40]
Perazella, M.A. Crystal-induced acute renal failure. Am. J. Med., 1999, 106(4), 459-465.
[http://dx.doi.org/10.1016/S0002-9343(99)00041-8] [PMID: 10225250]
[41]
Plosker, G.L.; Noble, S. Indinavir: a review of its use in the management of HIV infection. Drugs, 1999, 58(6), 1165-1203.
[http://dx.doi.org/10.2165/00003495-199958060-00011] [PMID: 10651394]
[42]
Izzedine, H.; Harris, M.; Perazella, M.A. The nephrotoxic effects of HAART. Nat. Rev. Nephrol., 2009, 5(10), 563-573.
[http://dx.doi.org/10.1038/nrneph.2009.142] [PMID: 19776778]
[43]
Rho, M.; Perazella, M.A. Nephrotoxicity associated with antiretroviral therapy in HIV-infected patients. Curr. Drug Saf., 2007, 2(2), 147-154.
[http://dx.doi.org/10.2174/157488607780598269] [PMID: 18690961]
[44]
Reilly, R.F.; Tray, K.; Perazella, M.A. Indinavir nephropathy revisited: a pattern of insidious renal failure with identifiable risk factors. Am. J. Kidney Dis., 2001, 38(4)E23
[http://dx.doi.org/10.1053/ajkd.2001.27732] [PMID: 11576910]
[45]
Lietman, P.S. Clinical pharmacology: foscarnet. Am. J. Med., 1992, 92(2A), 8S-11S.
[http://dx.doi.org/10.1016/0002-9343(92)90330-E] [PMID: 1371039]
[46]
Maurice-Estepa, L.; Daudon, M.; Katlama, C.; Jouanneau, C.; Sazdovitch, V.; Lacour, B.; Beaufils, H. Identification of crystals in kidneys of AIDS patients treated with foscarnet. Am. J. Kidney Dis., 1998, 32(3), 392-400.
[http://dx.doi.org/10.1053/ajkd.1998.v32.pm9740154] [PMID: 9740154]
[47]
Seidel, E.A.; Koenig, S.; Polis, M.A. A dose escalation study to determine the toxicity and maximally tolerated dose of foscarnet. AIDS, 1993, 7(7), 941-945.
[http://dx.doi.org/10.1097/00002030-199307000-00006] [PMID: 8357555]
[48]
Rusconi, S.; Innocenti, A.; Vullo, D.; Mastrolorenzo, A.; Scozzafava, A.; Supuran, C.T. Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet. Bioorg. Med. Chem. Lett., 2004, 14(23), 5763-5767.
[http://dx.doi.org/10.1016/j.bmcl.2004.09.064] [PMID: 15501037]

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