Login Register Cart 0
Generic placeholder image

Infectious Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Proposed Guidelines for the Management of ESBL in Prosthetic Joint Infections

Author(s): Suresh Antony*, Ismail Khan, Omer Chowdhury, Jacob Heydemann, Nishaal Antony, John Heydemann and David Isaac

Volume 20, Issue 5, 2020

Page: [563 - 569] Pages: 7

DOI: 10.2174/1871526519666190613121936

Price: $65

Abstract

The aim of this paper is to establish guidelines for the management of extendedspectrum beta-lactamases (ESBL) associated prosthetic joint infections (PJI). This study reviewed 21 patients in the literature documented with ESBL associated PJI. Literature suggests that patients with ESBL PJI are stratified into either early infections (<3 weeks) or late infections (>3 weeks), for which, appropriate laboratory and imaging studies need to be completed. Favorable outcomes require a two-stage revision with an antibiotic-impregnated spacer and a prolonged course of intravenous carbapenem antibiotic.

Keywords: Extended-spectrum beta-lactamases, prosthetic joint infections, infections, intravenous, carbapenem, antibiotic.

[1]
Kurtz, S.M.; Lau, E.; Watson, H.; Schmier, J.K.; Parvizi, J. Economic burden of periprosthetic joint infection in the United States. J. Arthroplasty, 2012, 27(8)(Suppl.), 61-65.
[http://dx.doi.org/10.1016/j.arth.2012.02.022] [PMID: 22554729]
[2]
Thaden, J.T.; Fowler, V.G.; Sexton, D.J.; Anderson, D.J. Increasing Incidence of Extended-Spectrum β-Lactamase-Producing Escherichia coli in Community Hospitals throughout the Southeastern United States. Infect. Control Hosp. Epidemiol., 2016, 37(1), 49-54.
[http://dx.doi.org/10.1017/ice.2015.239] [PMID: 26458226]
[3]
Kurtz, S.; Ong, K.; Lau, E.; Mowat, F.; Halpern, M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J. Bone Joint Surg. Am., 2007, 89(4), 780-785.
[PMID: 17403800]
[4]
Eka, A.; Chen, A.F. Patient-related medical risk factors for periprosthetic joint infection of the hip and knee. Ann. Transl. Med., 2015, 3(16), 233.
[PMID: 26539450]
[5]
Antony, S.J.; Parikh, M.S.; Soto, E.; Cameron, C.; Mody, R. Extended-Spectrum Beta-Lactamase Infections in Orthopedic-Related Devices and Prosthetic Joints. Orthopedics, 2016, 39(4), e668-e673.
[http://dx.doi.org/10.3928/01477447-20160606-07] [PMID: 27286048]
[6]
Martínez-Pastor, J.C.; Vilchez, F.; Pitart, C.; Sierra, J.M.; Soriano, A. Antibiotic resistance in orthopaedic surgery: acute knee prosthetic joint infections due to extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae. Eur. J. Clin. Microbiol. Infect. Dis., 2010, 29(8), 1039-1041.
[http://dx.doi.org/10.1007/s10096-010-0950-y] [PMID: 20473541]
[7]
Jhan, S-W.; Lu, Y-D.; Lee, M.S.; Lee, C-H.; Wang, J-W.; Kuo, F-C. The risk factors of failed reimplantation arthroplasty for periprosthetic hip infection. BMC Musculoskelet. Disord., 2017, 18(1), 255.
[http://dx.doi.org/10.1186/s12891-017-1622-1] [PMID: 28606121]
[8]
Lamagni, T. Epidemiology and burden of prosthetic joint infections. J. Antimicrob. Chemother., 2014, 69(Suppl. 1), i5-i10.
[http://dx.doi.org/10.1093/jac/dku247] [PMID: 25135091]
[9]
de Sanctis, J.; Teixeira, L.; van Duin, D.; Odio, C.; Hall, G.; Tomford, J.W.; Perez, F.; Rudin, S.D.; Bonomo, R.A.; Barsoum, W.K.; Joyce, M.; Krebs, V.; Schmitt, S. Complex prosthetic joint infections due to carbapenemase-producing Klebsiella pneumoniae: a unique challenge in the era of untreatable infections. Int. J. Infect. Dis., 2014, 25, 73-78.
[http://dx.doi.org/10.1016/j.ijid.2014.01.028] [PMID: 24813874]
[10]
Hsieh, P.H.; Lee, M.S.; Hsu, K.Y.; Chang, Y.H.; Shih, H.N.; Ueng, S.W. Gram-negative prosthetic joint infections: risk factors and outcome of treatment. Clin. Infect. Dis., 2009, 49(7), 1036-1043.
[http://dx.doi.org/10.1086/605593] [PMID: 19691430]
[11]
Martínez-Pastor, J.C.; Muñoz-Mahamud, E.; Vilchez, F.; García-Ramiro, S.; Bori, G.; Sierra, J.; Martínez, J.A.; Font, L.; Mensa, J.; Soriano, A. Outcome of acute prosthetic joint infections due to gram-negative bacilli treated with open debridement and retention of the prosthesis. Antimicrob. Agents Chemother., 2009, 53(11), 4772-4777.
[http://dx.doi.org/10.1128/AAC.00188-09] [PMID: 19687237]
[12]
Osmon, D.R.; Berbari, E.F.; Berendt, A.R.; Lew, D.; Zimmerli, W.; Steckelberg, J.M.; Rao, N.; Hanssen, A.; Wilson, W.R. Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin. Infect. Dis., 2013, 56(1), e1-e25.
[http://dx.doi.org/10.1093/cid/cis803] [PMID: 23223583]
[13]
Goswami, K.; Parvizi, J.; Maxwell Courtney, P. Current Recommendations for the Diagnosis of Acute and Chronic PJI for Hip and Knee-Cell Counts, Alpha-Defensin, Leukocyte Esterase, Next-generation Sequencing. Curr. Rev. Musculoskelet. Med., 2018, 11(3), 428-438.
[http://dx.doi.org/10.1007/s12178-018-9513-0] [PMID: 30062484]
[14]
Hanssen, A.D.; Osmon, D.R.; Nelson, C.L. Prevention of deep periprosthetic joint infection. JBJS, 1996, 78(3), 458-471.
[http://dx.doi.org/10.2106/00004623-199603000-00019]
[15]
Ure, K.J.; Amstutz, H.C.; Nasser, S.; Schmalzried, T.P. Direct-exchange arthroplasty for the treatment of infection after total hip replacement. An average ten-year follow-up. J. Bone Joint Surg. Am., 1998, 80(7), 961-968.
[http://dx.doi.org/10.2106/00004623-199807000-00004] [PMID: 9698000]
[16]
De Man, F.H.R.; Sendi, P.; Zimmerli, W.; Maurer, T.B.; Ochsner, P.E.; Ilchmann, T. Infectiological, functional, and radiographic outcome after revision for prosthetic hip infection according to a strict algorithm: 22 one-stage and 50 two-stage revisions with a mean follow-up time of 5 (2–17) years. Acta Orthop., 2011, 82(1), 27-34.
[http://dx.doi.org/10.3109/17453674.2010.548025] [PMID: 21189099]
[17]
Klouche, S.; Sariali, E.; Mamoudy, P. Total hip arthroplasty revision due to infection: A cost analysis approach. Orthopaedics &amp; Traumatology: Surgery &amp. Research., 2010, 96(2), 124-132.
[18]
Strange, S.; Whitehouse, M.R.; Beswick, A.D.; Board, T.; Burston, A.; Burston, B.; Carroll, F.E.; Dieppe, P.; Garfield, K.; Gooberman-Hill, R.; Jones, S.; Kunutsor, S.; Lane, A.; Lenguerrand, E.; MacGowan, A.; Moore, A.; Noble, S.; Simon, J.; Stockley, I.; Taylor, A.H.; Toms, A.; Webb, J.; Whittaker, J.P.; Wilson, M.; Wylde, V.; Blom, A.W. One-stage or two-stage revision surgery for prosthetic hip joint infection--the INFORM trial: a study protocol for a randomised controlled trial. Trials, 2016, 17(1), 90.
[http://dx.doi.org/10.1186/s13063-016-1213-8] [PMID: 26883420]
[19]
Jiranek, W.A.; Waligora, A.C.; Hess, S.R.; Golladay, G.L. Surgical Treatment of Prosthetic Joint Infections of the Hip and Knee: Changing Paradigms? J. Arthroplasty, 2015, 30(6), 912-918.
[http://dx.doi.org/10.1016/j.arth.2015.03.014] [PMID: 25922125]
[20]
Radoicic, D.; Milanovic, M.; Marinkovic, J.; Radoicic, D. Ertapenem Articulating Spacer for the Treatment of Polymicrobial Total Knee Arthroplasty Infection. Can. J. Infect. Dis. Med. Microbiol., 2016, 20165753489
[http://dx.doi.org/10.1155/2016/5753489] [PMID: 27366173]
[21]
James, A.; Larson, T. Acute renal failure after high-dose antibiotic bone cement: case report and review of the literature. Ren. Fail., 2015, 37(6), 1061-1066.
[http://dx.doi.org/10.3109/0886022X.2015.1052949] [PMID: 26056733]
[22]
Lichstein, P.; Gehrke, T.; Lombardi, A.; Romano, C.; Stockley, I.; Babis, G.; Bialecki, J.; Bucsi, L.; Cai, X.; Cao, L.; de Beaubien, B.; Erhardt, J.; Goodman, S.; Jiranek, W.; Keogh, P.; Lewallen, D.; Manner, P.; Marczynski, W.; Mason, J.B.; Mulhall, K.; Paprosky, W.; Patel, P.; Piccaluga, F.; Polkowski, G.; Pulido, L.; Stockley, I.; Suarez, J.; Thorey, F.; Tikhilov, R.; Velazquez, J.D.; Winkler, H. One-stage versus two-stage exchange. J. Orthop. Res., 2014, 32(S1)(Suppl. 1), S141-S146.
[http://dx.doi.org/10.1002/jor.22558] [PMID: 24464888]
[23]
Deccache, Y.; Irenge, L.M.; Ambroise, J.; Savov, E.; Marinescu, D.; Chirimwami, R.B.; Gala, J.L. A qPCR and multiplex pyrosequencing assay combined with automated data processing for rapid and unambiguous detection of ESBL-producers Enterobacteriaceae. AMB Express, 2015, 5(1), 136.
[http://dx.doi.org/10.1186/s13568-015-0136-1] [PMID: 26260895]
[24]
Cordero-Ampuero, J.; Esteban, J.; García-Cimbrelo, E. Oral antibiotics are effective for highly resistant hip arthroplasty infections. Clin. Orthop. Relat. Res., 2009, 467(9), 2335-2342.
[http://dx.doi.org/10.1007/s11999-009-0808-8] [PMID: 19333670]

Rights & Permissions Print Cite
Article Metrics
72
3
© 2024 Bentham Science Publishers | Privacy Policy