Fusogenic Viral Envelopes as Potent Vehicles for Gene Transfer

Title: Fusogenic Viral Envelopes as Potent Vehicles for Gene Transfer

Volume: 2 Issue: 3

Author(s): Evgeni G. Ponimaskin and Michael f.g. Schmidt

Affiliation:

Keywords: fusogenic viral envelopes, gene transfer, myxoviruses, non-viral gene transfer, liposome-Mediated gene transfer, virosomes

Abstract: The development of methods for efficiently introducing foreign genes into living cells provides novel tools to investigate intracellular processes at the molecular level. In addition, the development of suitable delivery vehicles for in vivo gene transfer is a prerequisite for clinical application of therapeutic genes. This review will summarize the current status of the development of both viral as well as non-viral vectors for gene therapy. In addition, we also discuss novel gene-delivery vehicles based on viral envelopes containing fusogenic spike proteins originated from different myxoviruses. These recombinant viral envelopes or virosomes could be viewed as hybrid vectors combining both viral and non-viral strategies, and are well suited for a wider application in therapeutic gene and drug delivery.

Cite this article as:

Ponimaskin G. Evgeni and Schmidt f.g. Michael, Fusogenic Viral Envelopes as Potent Vehicles for Gene Transfer, Current Genomics 2001; 2 (3) . https://dx.doi.org/10.2174/1389202013350814