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Endocrine, Metabolic & Immune Disorders - Drug Targets


ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Research Article

Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni

Author(s): Katia C. Oliveira, Rita Cardoso, Antonio C. Dos Santos, Ruben Fernandes and Monica C. Botelho*

Volume 19, Issue 8, 2019

Page: [1122 - 1126] Pages: 5

DOI: 10.2174/1871530319666190529121204

Price: $65


Objective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association in Schistosoma haematobium infection have already been described and it is known that the parasite produces a catechol-estrogen molecule that induces a hormonal imbalance in the host.

Methods: In order to better understand the relation of hormonal imbalance in experimental Schistosoma mansoni infection, we investigated a serum panel of steroid hormones in Schistosoma mansoni infected hamsters.

Results: We found a decrease in the serum levels of Estradiol (E2), Testosterone and Progesterone in infected females and an increase of Testosterone and a decrease in Progesterone in infected males in comparison with controls.

Conclusion: These results indicate that S. mansoni alters the levels of steroid hormones in infected males and females and it will increase the repertoire of data about the host-parasite molecular interplay and its relation with the endocrine system.

Keywords: Steroid hormones, Schistosoma mansoni infection, host-parasite interaction, estradiol, testosterone, progesterone, infertility.

Graphical Abstract
Botelho, M.C.; Ribeiro, R.; Vale, N. (...), Machado, J.C., Cor-reia Da Costa, J.M. Inactivation of estrogen receptor by Schis-tosoma haematobium total antigen in bladder urothelial cells. Oncol. Rep., 2012, 27(2), 356-362.
[PMID: 22089035]
Botelho, M.C.; Crespo, M.; Almeida, A.; Vieira, P.; Delgado, M.L.; Araujo, L.; Machado, J.C.; Correia da Costa, J.M. Schistosoma haematobium and Schistosomiasis mansoni: production of an estradiol-related compound detected by ELISA. Exp. Parasitol., 2009, 122(3), 250-253.
[] [PMID: 19361503]
Botelho, M.C.; Machado, J.C.; Brindley, P.J.; Correia da Costa, J.M. Targeting molecular signaling pathways of Schistosoma haemotobium infection in bladder cancer. Virulence, 2011, 2(4), 267-279.
[] [PMID: 21788729]
Linda, J. Heffner; Danny J. Schust. The Reproductive System at a Glance; John Wiley and Sons, 2010, p. 16.
Frye, C.A. Steroids, reproductive endocrine function, and affect. A review. Minerva Ginecol., 2009, 61(6), 541-562.
[PMID: 19942840]
Botelho, M.C.; Machado, J.C.; da Costa, J.M. Schistosoma haematobium and bladder cancer: what lies beneath? Virulence, 2010, 1(2), 84-87.
[] [PMID: 21178421]
Botelho, M.C.; Vale, N.; Gouveia, M.J.; Rinaldi, G.; Santos, J.; Santos, L.L.; Gomes, P.; Brindley, P.J.; Correia da Costa, J.M. Tumour-like phenotypes in urothelial cells after exposure to antigens from eggs of Schistosoma haematobium: an oestrogen-DNA adducts mediated pathway? Int. J. Parasitol., 2013, 43(1), 17-26.
[] [PMID: 23260770]
Santos, J.; Gouveia, M.J.; Vale, N. Delgado, Mde.L.; Gonçalves, A.; da Silva, J.M.; Oliveira, C.; Xavier, P.; Gomes, P.; Santos, L.L.; Lopes, C.; Barros, A.; Rinaldi, G.; Brindley, P.J.; da Costa, J.M.; Sousa, M.; Botelho, M.C. Urinary estrogen metabolites and self-reported infertility in women infected with Schistosoma haematobium. PLoS One, 2014, 9(5)e96774
[] [PMID: 24848950]
Hernández-Cervantes, R.; Quintanar-Stephano, A.; Moreno-Méndoza, N.; López-Griego, L.; López-Salazar, V.; Hernández-Bello, R.; Carrero, J.C.; Morales-Montor, J. Regulation of intestinal immune response by selective removal of the anterior, posterior, or entire pituitary gland in Trichinella spiralis infected golden hamsters. PLoS One, 2013, 8(3)e59486
[] [PMID: 23555042]
Saad, A.H.; Abdelbaky, A.; Osman, A.M.; Abdallah, K.F.; Salem, D. Possible role of Schistosoma mansoni infection in male hypogonadism. J. Egypt. Soc. Parasitol., 1999, 29(2), 307-323.
[PMID: 10605485]
Delmondes, L.M.; Cruz, M.A.; Guimarães, M.K.; Santana, L.G.; Gonçalves, V.P.; Brito, H.L. [Endocervical schistosomiasis: case report. Rev. Bras. Ginecol. Obstet., 2014, 36(6), 276-280.
[] [PMID: 25099468]
Badiale, G.B.; Brandão, D.F.; Ribeiro-Silva, A. [Endocervical schistosomiasis]. . Rev. Soc. Bras. Med. Trop., 2005, 38(4), 351-352.
[] [PMID: 16082486]
Habib, F.A.; Zaki, M.M.; El-Aal, A.A.; Safwat, M.D.; Domiaty, M.A. Immunohistochemical expression of oestrogen and progesterone receptors during experimental acute and chronic murine Schistosomiasis mansoni. Rev. Soc. Bras. Med. Trop., 2010, 43(5), 531-535.
[] [PMID: 21085864]
Escobedo, G.; Roberts, C.W.; Carrero, J.C.; Morales-Montor, J. Parasite regulation by host hormones: an old mechanism of host exploitation? Trends Parasitol., 2005, 21(12), 588-593.
[] [PMID: 16236553]
Ryan, K.J. Biochemistry of aromatase: significance to female reproductive physiology. Cancer Res., 1982, 42(8)(Suppl.), 3342s-3344s.
[PMID: 7083198]
Patel, B.; Elguero, S.; Thakore, S.; Dahoud, W.; Bedaiwy, M.; Mesiano, S. Role of nuclear progesterone receptor isoforms in uterine pathophysiology. Hum. Reprod. Update, 2015, 21(2), 155-173.
[] [PMID: 25406186]
Gailly-Fabre, E.; Kerlan, V.; Christin-Maitre, S. [Pregnancy-associated hormones and fetal-maternal relations. Ann. Endocrinol. (Paris), 2015, 76(6)(Suppl. 1), S39-S50.
[] [PMID: 26776288]
Shah, C.; Modi, D.; Gadkar, S.; Sachdeva, G.; Puri, C. Progesterone receptors on human spermatozoa. Indian J. Exp. Biol., 2003, 41(7), 773-780.
[PMID: 15255380]
Mooradian, A.D.; Morley, J.E.; Korenman, S.G. Biological actions of androgens. Endocr. Rev., 1987, 8(1), 1-28.
[] [PMID: 3549275]
Kasilima, Y.S.; Wango, E.O.; Kigondu, C.S.; Mutayoba, B.M.; Nyindo, M. Plasma bioactive LH and testosterone profiles in male New Zealand rabbits experimentally infected with Schistosoma mansoni. Acta Trop., 2004, 92(3), 165-172.
[] [PMID: 15533284]
Lansoud-Soukate, J.; Leonardelli, J.; Torpier, G.; Croix, D.; Capron, A. [Role of Schistosoma mansoni bilharziasis in male hypogonadism] Pathol. Biol. (Paris), 1991, 39(7), 681-685.
[PMID: 1758719]
Abdalla, K.F.; Abdel-Aziz, S.M.; el Fakahany, A.F.; el-Hamshary, A.S.; Afifi, L.M. Effect of praziquantel on sex hormone levels in murine schistosomiasis mansoni. J. Egypt. Soc. Parasitol., 1994, 24(3), 627-632.
[PMID: 7844428]
Skelly, P.J.; Secor, W.E.; Reis, M.G.; Ramos, E.A.; Carmo, T.M.; Peixoto, E.E.; Harn, D.A. Failure of schistosomiasis to significantly decrease testosterone levels in Brazilian men. Am. J. Trop. Med. Hyg., 1994, 51(1), 40-44.
[] [PMID: 8059914]
Shlomo Melmed. 2016Williams Textbook of Endocrinology. Elsevier Health Sciences. 710..
Handelsman, D.J.; Conway, A.J.; Boylan, L.M. Suppression of human spermatogenesis by testosterone implants. J. Clin. Endocrinol. Metab., 1992, 75(5), 1326-1332.
[PMID: 1430094]
Romano, M.C.; Jiménez, P.; Miranda-Brito, C.; Valdez, R.A. Parasites and steroid hormones: corticosteroid and sex steroid synthesis, their role in the parasite physiology and development. Front. Neurosci., 2015, 9, 224.
[] [PMID: 26175665]

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