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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Research Article

Synthesis and in vitro Antitumor Effect of New Vindoline Derivatives Coupled with Triphenylphosphine

Author(s): András Keglevich*, Áron Szigetvári, Miklós Dékány, Csaba Szántay, Péter Keglevich and László Hazai*

Volume 23, Issue 7, 2019

Page: [852 - 858] Pages: 7

DOI: 10.2174/1385272823666190524083236

open access plus


An important approach to the development of new antitumor agents is the synthesis of conjugates containing two or more structural units. Taking this into consideration, vindoline derivatives were coupled with triphenylphosphine, to afford the expected phosphonium salts. The new hybrid entities were characterized by NMR spectroscopy, and their anticancer activity was also evaluated.

Keywords: Anticancer drugs, dimer Vinca alkaloids, vindoline, triphenylphosphine, phosphonium salts, antiproliferative activity.

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