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Current Respiratory Medicine Reviews


ISSN (Print): 1573-398X
ISSN (Online): 1875-6387

Review Article

Towards Precision Medicine in Pediatric Severe Asthma: An Update on Current and Emerging Biomarkers

Author(s): Amelia Licari, Riccardo Castagnoli, Enrica Manca, Martina Votto, Alexander Michev and Gian Luigi Marseglia*

Volume 15, Issue 3, 2019

Page: [187 - 194] Pages: 8

DOI: 10.2174/1573398X15666190423150227


Pediatric severe asthma is actually considered a rare disease with a heterogeneous nature. Recent cohort studies focusing on children with severe asthma identified different clinical presentations (phenotypes) and underlying pathophysiological mechanisms (endotypes). Phenotyping and endotyping asthma represent the current approach to patients with severe asthma and consist in characterizing objectively measurable and non-invasive indicators (biomarkers) capable of orienting diagnosis, management and personalized treatment, as advocated by the Precision Medicine approach. The aim of this review is to provide a practical overview of current and emerging biomarkers in pediatric severe asthma.

Keywords: Biomarkers, eosinophils, fractional exhaled nitric oxide, IgE, neutrophils, pediatric, periostin, severe asthma.

Graphical Abstract
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