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Current Vascular Pharmacology


ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

General Review Article

Arterial Stiffness, Cognitive Dysfunction and Adherence to Antihypertensive Agents. Is there a Link to Hypertensive Patients?

Author(s): Rigas G. Kalaitzidis*, Thalia Panagiotopoulou, Dimitrios Stagikas, Kosmas Pappas, Olga Balafa and Moses S. Elisaf

Volume 18, Issue 4, 2020

Page: [410 - 417] Pages: 8

DOI: 10.2174/1570161117666190415112953

Price: $65


The incidence of hypertension (HTN) and its cardiovascular (CV) complications are increasing throughout the world. Blood pressure (BP) control remains unsatisfactory worldwide. Medical inertia and poor adherence to treatment are among the factors that can partially explain, why BP control rate remains low. The introduction of a method for measuring the degree of adherence to a given medication is now a prerequisite. Complex treatment regimes, inadequate tolerance and frequent replacements of pharmaceutical formulations are the most common causes of poor adherence. In contrast, the use of stable combinations of antihypertensive drugs leads to improved patient adherence.

We aim to review the relationships between arterial stiffness, cognitive function and adherence to medication in patients with HTN.

Large artery stiffening can lead to HTN. In turn, arterial stiffness induced by HTN is associated with an increased CV and stroke risk. In addition, HTN can induce disorders of brain microcirculation resulting in cognitive dysfunction. Interestingly, memory cognitive dysfunction leads to a reduced adherence to drug treatment. Compliance with antihypertensive treatment improves BP control and arterial stiffness indices. Early treatment of arterial stiffness is strongly recommended for enhanced cognitive function and increased adherence.

Keywords: Hypertension, arterial stiffness, cognitive dysfunction, adherence to medication, cardiovascular disease, arterial pressure.

Graphical Abstract
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