Abstract
Benzamide riboside (BR), a recent synthetic nucleoside analogue, is a new compound demonstrating potent cytotoxic activity in malignant cell lines in vitro and in vivo in L1210 leukemia. It exhibits at least two different mechanisms of action. These are, first, the inhibition of inosine 5-monophosphate dehydrogenase (IMPDH, EC 1.1.1.205), a rate-limiting enzyme for GTP and dGTP synthesis that plays a major role in DNA synthesis, cell proliferation and regulation and second, the induction of apoptosis. Some aspects of BR activity in malignant cells in vitro and in vivo are reviewed as well as some of the mechanisms behind BRs anti-neoplastic effect.
Keywords: antitumor activity, benzamide riboside, staurosporine, cytarabine, cisplatin, combination therapy, apoptosis
Current Medicinal Chemistry
Title: Antitumor Activity of Benzamide Riboside In Vitro and In Vivo
Volume: 9 Issue: 7
Author(s): Ladislav Novotny, Peter Rauko, Joel A. Yalowitz and Thomas Szekeres
Affiliation:
Keywords: antitumor activity, benzamide riboside, staurosporine, cytarabine, cisplatin, combination therapy, apoptosis
Abstract: Benzamide riboside (BR), a recent synthetic nucleoside analogue, is a new compound demonstrating potent cytotoxic activity in malignant cell lines in vitro and in vivo in L1210 leukemia. It exhibits at least two different mechanisms of action. These are, first, the inhibition of inosine 5-monophosphate dehydrogenase (IMPDH, EC 1.1.1.205), a rate-limiting enzyme for GTP and dGTP synthesis that plays a major role in DNA synthesis, cell proliferation and regulation and second, the induction of apoptosis. Some aspects of BR activity in malignant cells in vitro and in vivo are reviewed as well as some of the mechanisms behind BRs anti-neoplastic effect.
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Cite this article as:
Novotny Ladislav, Rauko Peter, Yalowitz A. Joel and Szekeres Thomas, Antitumor Activity of Benzamide Riboside In Vitro and In Vivo, Current Medicinal Chemistry 2002; 9 (7) . https://dx.doi.org/10.2174/0929867024606894
DOI https://dx.doi.org/10.2174/0929867024606894 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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