Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

A Review on the Most Important Medicinal Plants Effective in Cardiac Ischemia-Reperfusion Injury

Author(s): Mehrnoosh Sedighi, Robert D. E. Sewell, Afshin Nazari, Saber Abbaszadeh, Mostafa Cheraghi, Abdolhakim Amini, Zahra Heydari and Mahmoud Rafieian-Kopaei*

Volume 25, Issue 3, 2019

Page: [352 - 358] Pages: 7

DOI: 10.2174/1381612825666190329144016

Price: $65

Abstract

Ischemia, referring to reduction and restriction of perfusion to myocardial tissue which involves coronary artery through the formation of misplaced clots and thrombosis, is one of the most important cardiovascular diseases. Plant-based compounds help to improve or prevent disease by affecting the factors involved in the disease. This review was conducted to report the medicinal plants and factors effective in cardiac ischemiareperfusion (I/R) injury to supplement the knowledge about this disease and its prevention and treatment using certain medicinal plants and their active compounds. For this purpose, medicinal plants and their potential antioxidant activities, effects on lipid levels and plaque formation, atherosclerosis and development of cardiovascular diseases and ischemia were reviewed.

Methods: To conduct this review, relevant articles published between 1983 and 2018 were retrieved from the Google Scholar, PubMed, Scientific Information Database, Web of Science, and Scopus using search terms antioxidant, ischemia, reperfusion, heart, infarct, inflammation, cholesterol and medicinal plants. Then, the eligible articles were reviewed.

Results: The active compounds of plants, including phenolic compounds, flavonoids, and antioxidant compounds, can be effective on certain pathogenic factors particularly in decreasing cholesterol and blood pressure, preventing an increase in free radicals and ultimately reducing blood clots and vascular resistance to reduce and prevent ischemic disease and its harmful effects.

Conclusion: Medicinal plants discussed in this article seem to be able to prevent cardiac damage and the disease progression via affecting the factors that are involved in ischemia.

Keywords: Cardiac ischemia, antioxidant, blood, cholesterol, infarction, medicinal plants.

[1]
Thom TJ. International mortality from heart disease: rates and trends. Int J Epidemiol 1989; 18(3)(Suppl. 1): S20-8.
[2]
Pearson TA, Mensah GA, Alexander RW, et al. AHA/CDC scientific statement. Circulation 2003; 107: 499-511.
[3]
Landmesser U, Spiekermann S, Dikalov S, et al. Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase. Circulation 2002; 106(24): 3073-8.
[4]
Kotur-Stevuljevic J, Memon L, Stefanovic A, et al. Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients. Clin Biochem 2007; 40(3-4): 181-7.
[5]
Asadi-Samani M, Bahmani M. Trends on the treatment of atherosclerosis; new improvements. Angiol Persica Acta 2016; 1(1)e01
[6]
Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001; 21(1): 2-14.
[7]
de Waard MC, van Haperen R, Soullié T, Tempel D, de Crom R, Duncker DJ. Beneficial effects of exercise training after myocardial infarction require full eNOS expression. J Mol Cell Cardiol 2010; 48(6): 1041-9.
[8]
Tzivoni D, Keren A, Granot H, Gottlieb S, Benhorin J, Stern S. Ventricular fibrillation caused by myocardial reperfusion in Prinzmetal’s angina. Am Heart J 1983; 105(2): 323-5.
[9]
Tavafi M. Suggestions for attenuation of renal ischemia reperfusion injury based on mechanisms involved in epithelial cells damages. J Nephropharmacol 2015; 4(1): 1-3.
[10]
Ahmadvand H, Babaeenezhad E, Hadipour-Moradi F, Cheraghi-Venool A. Effect of gallic acid on liver oxidative stress markers in renal ischemia-reperfusion injury in rats. Ann Res Antioxid 2017; 2(1)e03
[11]
Hasanvand A. Ischemia and post-injury regeneration in proximal convoluted tubule cells. Acta Persica Pathophysiol 2017; 2e01
[12]
Piper HM, Meuter K, Schäfer C. Cellular mechanisms of ischemia-reperfusion injury. Ann Thorac Surg 2003; 75(2): S644-8.
[13]
Manning AS, Hearse DJ. Reperfusion-induced arrhythmias: mechanisms and prevention. J Mol Cell Cardiol 1984; 16(6): 497-518.
[14]
Tiet Z. Fundamentals of clinical chemistry Philadelphia. W.B. Saunders, Philadelphia 2001:352-66.
[15]
Capstick T, Henry MT. Efficacy of thrombolytic agents in the treatment of pulmonary embolism. Eur Respir J 2005; 26(5): 864-74.
[16]
Levine MN, Raskob G, Landefeld S, Kearon C. Hemorrhagic complications of anticoagulant treatment. Chest 2001; 119(1)(Suppl.): 108S-21S.
[17]
Wardlaw JMBE, Zoppo G, Yamaguchi T. Thrombolysis for acute ischemic stroke. Stroke 2004; 35: 2914-5.
[18]
Kee NLA, Mnonopi N, Davids H, Naudé RJ, Frost CL. Antithrombotic/anticoagulant and anticancer activities of selected medicinal plants from South Africa. Afr J Biotechnol 2008; 7(3): 217-23.
[19]
Heidari M, Norooz Zadeh R, Abbasi M. The use of herbal drugs in cardiovascular diseases: A review article. Iran J Cardiovasc Nurs 2013; 2: 70-7.
[20]
Walden R, Tomlinson B. 16 Cardiovascular Disease. Biomol Clin Aspects 2011; p. 333.
[21]
Hearse DJ. Myocardial ischaemia: can we agree on a definition for the 21st century? Cardiovasc Res 1994; 28(12): 1737-44.
[22]
Jong JW, et al. The role of adenosine in preconditioning. Pharmacol Ther 2000; 87: 14-9.
[23]
Ganz PGW. Hypertensive and artherosclerotic cardiovascula rdisease: Coronary blood flow and my ocardial ischemia. Heart Disease W.B. Saunders, USA 2001: 600-5.
[24]
Sommerschild HT, Kirkebøen KA. Preconditioning - endogenous defence mechanisms of the heart. Acta Anaesthesiol Scand 2002; 46(2): 123-37.
[25]
Liem DA, Honda HM, Zhang J, Woo D, Ping P. Past and present course of cardioprotection against ischemia-reperfusion injury. J Appl Physiol 2007; 103(6): 2129-36.
[26]
Braunwald E, Kloner RA. Myocardial reperfusion: A double-edged sword? J Clin Invest 1985; 76(5): 1713-9.
[27]
Moens AL, Claeys MJ, Timmermans JP, Vrints CJ. Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process. Int J Cardiol 2005; 100(2): 179-90.
[28]
Raedschelders K, Ansley DM, Chen DD. The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion. Pharmacol Ther 2012; 133(2): 230-55.
[29]
Gross GJKJ, Kersten JR, Warltier DC. Mechanisms of post-ischemic contractile dysfunction. Ann Thorac Surg 1999; 68(5): 1898-904.
[30]
Neves LA, Almeida AP, Khosla MC, Campagnole-Santos MJ, Santos RA. Effect of angiotensin-(1-7) on reperfusion arrhythmias in isolated rat hearts. Braz J Med Biol Res 1997; 30(6): 801-9.
[31]
Kloner RA, Giacomelli F, Alker KJ, Hale SL, Matthews R, Bellows S. Influx of neutrophils into the walls of large epicardial coronary arteries in response to ischemia/reperfusion. Circulation 1991; 84(4): 1758-72.
[32]
Brown DA, Jew KN, Sparagna GC, Musch TI, Moore RL. Exercise training preserves coronary flow and reduces infarct size after ischemia-reperfusion in rat heart. J Appl Physiol 2003; 95(6): 2510-8.
[33]
Talebizadeh N, Haghdoust A, Mirzazadeh A. Epidemiology Model of Ischemic Heart Disease in Iran. Payesh Quarterly 1998; 8: 163-70.
[34]
Chen L-L, Yin H, Huang J. Inhibition of TGF-β1 signaling by eNOS gene transfer improves ventricular remodeling after myocardial infarction through angiogenesis and reduction of apoptosis. Cardiovasc Pathol 2007; 16(4): 221-30.
[35]
Murohara T, Asahara T. Nitric oxide and angiogenesis in cardiovascular disease. Antioxid Redox Signal 2002; 4(5): 825-31.
[36]
Wu G, Rana JS, Wykrzykowska J, et al. Exercise-induced expression of VEGF and salvation of myocardium in the early stage of myocardial infarction. Am J Physiol Heart Circ Physiol 2009; 296(2): H389-95.
[37]
Naseem KM. The role of nitric oxide in cardiovascular diseases. Mol Aspects Med 2005; 26(1-2): 33-65.
[38]
Dulak J, Józkowicz A, Guevara I, Dembińska-Kieć A. Gene transfer of vascular endothelial growth factor and endothelial nitric oxide synthase--implications for gene therapy in cardiovascular diseases. Pol J Pharmacol 1999; 51(3): 233-41.
[39]
Eugen B. The History in: Braunwald E. Heart Dis 1997; 12.
[40]
de Medeiros JMR, Macedo M, Contancia JP, Nguyen C, Cunningham G, Miles DH. Antithrombin activity of medicinal plants of the Azores. J Ethnopharmacol 2000; 72(1-2): 157-65.
[41]
Rastegari F. The healthy diet for cardiovascular disease. Acta Persica Pathophysiol 2016; 1e02
[42]
Rashidi B, Mohammadi M, Mirzaei F, Badalzadeh R, Reisi P. Amlodipine treatment decreases plasma and carotid artery tissue levels of endothelin-1 in atherosclerotic rabbits. Pathophysiology 2011; 18(2): 137-42.
[43]
Gürbüz I, Akyüz C, Yeşilada E, Şener B. Anti-ulcerogenic effect of Momordica charantia L. fruits on various ulcer models in rats. J Ethnopharmacol 2000; 71(1-2): 77-82.
[44]
Khan IA, Abourashed EA. Leung’s encyclopedia of common natural ingredients: used in food, drugs and cosmetics 2002. 23-97.
[45]
El-Arab AE, Foheid S, El-Said M. Effect of yeast and botanical beta-glucan on serum lipid profile and cecum probiotic bacteria using rats fed cholesterol diet. Pol J Food Nutr Sci 2009; 59: 169-74.
[46]
Najafi M, Vaez H, Zahednezhad F, Samadzadeh M, Babaei H. Study the effects of hydroalcoholic extract of grape seed (Vitis vinifera) on infarct size and cardiac arrhythmias in ischemic-reperfused isolated rat heart. Pharm Sci 2011; 16: 187-94.
[47]
Lusby PE, Coombes A, Wilkinson JM. Honey: A potent agent for wound healing? J Wound Ostomy Continence Nurs 2002; 29(6): 295-300.
[48]
Nègre-Salvayre A, Salvayre R. Quercetin prevents the cytotoxicity of oxidized LDL on lymphoid cell lines. Free Radic Biol Med 1992; 12(2): 101-6.
[49]
Hozayen W, Bastawy M, Elshafeey H. Effects of aqueous purslane (Portulaca oleracea) extract and fish oil on gentamicin nephrotoxicity in albino rats. Nat Sci 2011; 9: 47-62.
[50]
Daels-Rakotoarison DA, Gressier B, Trotin F, et al. Effects of Rosa canina fruit extract on neutrophil respiratory burst. Phytother Res 2002; 16(2): 157-61.
[51]
Fuster V RR, Walsh R, Pool-Wilson Ph. Hurst the heart. China: Mc Graw-Hill companies 2008; 12
[52]
de Nigris F, Balestrieri ML, Williams-Ignarro S, et al. The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats. Nitric Oxide 2007; 17(1): 50-4.
[53]
Rameshrad M, Vaez H, Toutounchi NS, Fathiazad F, Garjani A. Effect of methanolic extract of marrubium crassidens boiss on ischemia/reperfusion induced arrhythmias and infarct size in isolated rat heart. Pharm Sci 2014; 20: 80.
[54]
Niazmand S, Ahmadpour E, Mousavian M, Saberi Z. The inotropic and chronotropic effects of aqueous ethanolic extract from teucrium polium.on guinea pig isolated heart. Majallah-i Danishgah-i Ulum-i Pizishki-i Babul 2008; 10: 7-13.
[55]
Santos RL, Abreu GR, Bissoli NS, Moysés MR. Endothelial mediators of 17 beta-estradiol-induced coronary vasodilation in the isolated rat heart. Braz J Med Biol Res 2004; 37(4): 569-75.
[56]
Andreadou I, Iliodromitis EK, Mikros E, et al. The olive constituent oleuropein exhibits anti-ischemic, antioxidative, and hypolipidemic effects in anesthetized rabbits. J Nutr 2006; 136(8): 2213-9.
[57]
Liu N, Yang Y, Mo S, Liao J, Jin J. Calcium antagonistic effects of Chinese crude drugs: preliminary investigation and evaluation by 45 Ca. Appl Radiat Isot 2005; 63(2): 151-5.
[58]
Xi L, Qian Z, Xu G, et al. Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats. J Nutr Biochem 2007; 18(1): 64-72.
[59]
Naderi Gh. Jafari Dinani N, Jafarian Dehkordi A, Asgari S. Shami Analysis of the compounds in the four-seasoned essential oil and study the fibrinolytic activity of these compounds in the in vitro environment. Physiology and Pharmacology 1988; 4: 423-9.
[60]
Sadeghi N, Dianat M, Badavi M, Malekzadeh A. Cardioprotective effect of aqueous extract of Chichorium intybus on ischemia-reperfusion injury in isolated rat heart. Avicenna J Phytomed 2015; 5(6): 568-75.
[61]
Khaksari M, Sajadi M, Bahremand F, Vefa M. Effect of kidney bean and chicory diets on control of blood sugar in diabetic rats. Kowsar Medical Journal 2001; 6: 1-8.
[62]
Zheng S-Y, Sun J, Zhao X, Xu J-G. Protective effect of shen-fu on myocardial ischemia-reperfusion injury in rats. Am J Chin Med 2004; 32(2): 209-20.
[63]
Štajner D, Popović BM, Canadanović-Brunet J, Štajner M. Antioxidant and scavenger activities of Allium ursinum. Fitoterapia 2008; 79(4): 303-5.
[64]
Hiyasat B, Sabha D, Grötzinger K, et al. Antiplatelet activity of Allium ursinum and Allium sativum. Pharmacology 2009; 83(4): 197-204.
[65]
Joukar S, Asadipour H, Sheibani M, Najafipour H, Dabiri S. The effects of Melissa officinalis (lemon balm) pretreatment on the resistance of the heart to myocardial injury. Pharm Biol 2016; 54(6): 1005-13.
[66]
Coruh N, Celep AS, Özgökçe F, İşcan M. Antioxidant capacities of Gundelia tournefortii L. extracts and inhibition on glutathione-S-transferase activity. Food Chem 2007; 100: 1249-53.
[67]
Rietz B, Isensee H, Strobach H, Makdessi S, Jacob R. Cardioprotective actions of wild garlic (Allium ursinum) in ischemia and reperfusion. Mol Cell Biochem 1993; 119(1-2): 143-50.
[68]
Kabiri N, Setorki M. Regression of hypercholesterolemic atherosclerosis in rabbits by hydroalcoholic extracts of Hypericum perforatum. J Med Plants Res 2012; 6: 2540-9.
[69]
Sedighi M, Nazari A, Faghihi M, et al. Protective effects of cinnamon bark extract against ischemia-reperfusion injury and arrhythmias in rat. Phytother Res 2018; 32(10): 1983-91.
[70]
Jalilzadeh-Amin G, Anassori E, Namvar M-T. Renal ischemia/reperfusion injury; from pathophysiology to treatment. J Renal Inj Prev 2015; 4(2): 20-7.
[71]
Malek M, Nematbakhsh M. Renal ischemia/reperfusion injury; from pathophysiology to treatment. J Renal Inj Prev 2015; 4(2): 20-7.
[72]
Baradaran A. Administration of herbal drugs in geriatric individuals; trends on its helps and hazards. Geriatr Persia 2017; 1(1)e01
[73]
Gensini GF, Comeglio M, Colcila A. Hemostatic factors, atherogenesis and atherosclerosis. Biomed Pharmacother 1996; 8: 395.
[74]
Leopold JA, Loscalzo J. Oxidative risk for atherothrombotic cardiovascular disease. Free Radic Biol Med 2009; 47(12): 1673-706.
[75]
Siregar S, Romdam T, Stanzah H, Firmansyah I. The effect of long-acting PDE-5 inhibitor on renal ischemia/reperfusion injury in Wistar rats; a study on serum cystatin C and renal histopathological findings. J Nephropathol 2019; 8(1)e07
[76]
Shahzamani F, Monajemi R, Nematbakhsh M. High-salt intake during pregnancy may influence the outcome of renal ischemia/reperfusion in adult offspring. J Renal Inj Prev 2018; 7(2): 69-72.
[77]
de Wardener HE. Salt reduction and cardiovascular risk: the anatomy of a myth. J Hum Hypertens 1999; 13(1): 1-4.
[78]
Chen Y, Reaven G. Insulin resistance and atherosclerosis. Diabetes Rev (Alex) 1997; 5: 331-42.
[79]
Tiet Z. Fundamentals of clinical chemistry. 5th ed. 2001; pp. 352-66.
[80]
Pérez JM, Arenas FA, Pradenas GA, Sandoval JM, Vásquez CC. Escherichia coli YqhD exhibits aldehyde reductase activity and protects from the harmful effect of lipid peroxidation-derived aldehydes. J Biol Chem 2008; 283(12): 7346-53.
[81]
Mohammadi MRM, Rasouli M. Laboratory of Medical Biochemistry 1 and 2. 2015; 1.
[82]
Basso C, Calabrese F, Corrado D, Thiene G. Postmortem diagnosis in sudden cardiac death victims: macroscopic, microscopic and molecular findings. Cardiovasc Res 2001; 50(2): 290-300.
[83]
Burtis CA. Ash wood ER Fundamentals of Clinical Chemistry. 5th ed. 2001.
[84]
Greager MA, Libby P, Zipes DP, Bonow RO, Braunwald E. Peripheral arterial disease.Braunwald’s heart disease: A textbook of cardiovascular medicine 7th ed. 2005; 1437-61.
[85]
Kumar S, Kumar D. Evaluation of antioxidant potential, phenolic and flavonoid contents of hibiscus liliaceous flowers. EJAF CHE 2008; 7: 2863-71.
[86]
Nasri H. Help or hindrance; administration of herbal drugs for kidney diseases. Toxicol Persa 2016; 1(1)e04
[87]
Baradaran A. The role of biomarkers to detect progression of diseases. J Negat Results Clin Exp Stud 2018; 1(1)e05
[88]
Dehghan Shahreza F. Oxidative stress, free radicals, kidney disease and plant antioxidants. Immunopathol Persa 2017; 3(2)e11
[89]
Nasri H. Trends toward amelioration of renal inflammation and fibrosis in various kidney diseases. J Inj Inflamm 2016; 1(1)e02
[90]
Dehghan Shahreza F. Vascular protection by herbal antioxidants; recent views and new concepts. J Prev Epidemiol 2016; 1(1)e05
[91]
Grenett H, Abou-Agag L, Parks D, Booyse F. Ethanol and polyphenols (CAT, QUER) increase expression of fibrinolytic protein mRNAs in vivo in rat aortic endothelium. Biol Res 2004; 37: 342.
[92]
Prasad K, Kalra J. Oxygen free radicals and hypercholesterolemic atherosclerosis: effect of vitamin E. Am Heart J 1993; 125(4): 958-73.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy