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Current Bioactive Compounds


ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Review Article

Modification in the Natural Bioactive Molecule: Piperine; A Continuing Source for the Drug Development

Author(s): Bhawna Chopra*, Ashwani K. Dhingra and Deo N. Prasad

Volume 16, Issue 6, 2020

Page: [714 - 725] Pages: 12

DOI: 10.2174/1573407215666190318125023

Price: $65


Background: Piperine, a bioactive alkaloid was a well-known component which was used traditionally to treat a variety of disorders.

Objective: The present review is to discuss the modified piperine or piperic acid analogs or its derivatives to explore the potential of piperine. Piperine or piperic acid had potentials as antibacterial, antitumor, antioxidant, anti-inflammatory, antifungal, immunomodulatory and many more for drug development. So modification in natural molecule piperine generates numerous derivatives or analogues which may be found beneficial in drug development.

Methods: A literature survey has been carried out to determine the real potential of piperine and its modified analogs.

Results: It has been scrutinized that piperine and its derivatives possess valuable components with good therapeutic potential.

Conclusion: Thus, this review aims to provide knowledge as well as to explore the excellent potential of piperine, piperic acid, piperine derived compounds/ analogs which may further, after performing toxicity studies, and other parameters, be helpful in the design and development of novel drug candidates against numerous disease conditions and thus it paves way for further work in exploring the potential to treat the patients with obesity and skin related disorders.

Keywords: Efflux pump, piperine, piperic acid, in silico, fat fighter, stereochemical factors.

Graphical Abstract
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