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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Protein/ Hormone Based Nanoparticles as Carriers for Drugs Targeting Protein-Protein Interactions

Author(s): Ebtesam Al-Suhaimi*, Vijaya Ravinayagam, B. Rabindran Jermy, Tarhini Mohamad and Abdelhamid Elaissari

Volume 19, Issue 6, 2019

Page: [444 - 456] Pages: 13

DOI: 10.2174/1568026619666190304152320

Price: $65


Background: In this review, protein-protein interactions (PPIs) were defined, and their behaviors in normal in disease conditions are discussed. Their status at nuclear, molecular and cellular level was underscored, as for their interference in many diseases. Finally, the use of protein nanoscale structures as possible carriers for drugs targeting PPIs was highlighted.

Objective: The objective of this review is to suggest a novel approach for targeting PPIs. By using protein nanospheres and nanocapsules, a promising field of study can be emerged.

Methods: To solidify this argument, PPIs and their biological significance was discussed, same as their role in hormone signaling.

Results: We shed the light on the drugs that targets PPI and we suggested the use of nanovectors to encapsulate these drugs to possibly achieve better results.

Conclusion: Protein based nanoparticles, due to their advantages, can be suitable carriers for drugs targeting PPIs. This can open a new opportunity in the emerging field of multifunctional therapeutics.

Keywords: Protein-protein interactions, Nanoparticles, Drug carriers, Nano-peptide hormone, Protein based nanoparticles, Computational modelling.

Graphical Abstract
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