Abstract
Despite advances in neuro-imaging, neurosurgery, radiation therapy, and chemotherapy, limited progress has been made in the treatment of patients with high-grade astrocytomas. Primary brain tumours are considered to be among the most difficult neoplasms to treat which is largely due to the invasive nature of these tumours and the complexity of the organ in which they arise. In an attempt to overcome some of the limitations of systemic delivery of anticancer drugs, several methods of localised delivery have been developed. In this article we briefly review some of the current literature on systems for localised delivery of therapeutic agents to brain tumors, which consists of osmotic mini-pumps, infusion pumps (convectionenhanced delivery), and cell grafting. Furthermore, special emphasis is made on bio-degradable polymers, which is at present the best characterised system of local delivery to brain tumors, along with a promising novel delivery system, based on non-degradable polymer encapsulated cell therapy.
Keywords: Localised Delivery, CNS Malignancies, neuro-imaging, astrocytomas, bio-degradable polymers, cell therapy, osmotic mini-pumps, cell grafting, polymer matrix
Current Pharmaceutical Biotechnology
Title: Localised Delivery of Therapeutic Agents to CNS Malignancies: Old and New Approaches
Volume: 3 Issue: 3
Author(s): Tracy-Ann Read, Frits Thorsen and Rolf Bjerkvig
Affiliation:
Keywords: Localised Delivery, CNS Malignancies, neuro-imaging, astrocytomas, bio-degradable polymers, cell therapy, osmotic mini-pumps, cell grafting, polymer matrix
Abstract: Despite advances in neuro-imaging, neurosurgery, radiation therapy, and chemotherapy, limited progress has been made in the treatment of patients with high-grade astrocytomas. Primary brain tumours are considered to be among the most difficult neoplasms to treat which is largely due to the invasive nature of these tumours and the complexity of the organ in which they arise. In an attempt to overcome some of the limitations of systemic delivery of anticancer drugs, several methods of localised delivery have been developed. In this article we briefly review some of the current literature on systems for localised delivery of therapeutic agents to brain tumors, which consists of osmotic mini-pumps, infusion pumps (convectionenhanced delivery), and cell grafting. Furthermore, special emphasis is made on bio-degradable polymers, which is at present the best characterised system of local delivery to brain tumors, along with a promising novel delivery system, based on non-degradable polymer encapsulated cell therapy.
Export Options
About this article
Cite this article as:
Read Tracy-Ann, Thorsen Frits and Bjerkvig Rolf, Localised Delivery of Therapeutic Agents to CNS Malignancies: Old and New Approaches, Current Pharmaceutical Biotechnology 2002; 3 (3) . https://dx.doi.org/10.2174/1389201023378346
DOI https://dx.doi.org/10.2174/1389201023378346 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Taking Cell Culture in Drug Discovery to the Third Dimension - A Patent Review
Recent Patents on Biomedical Engineering (Discontinued) The Application of lncRNAs in Cancer Treatment and Diagnosis
Recent Patents on Anti-Cancer Drug Discovery Medicinal Chemistry of Drugs with Active Metabolites Following Conjugation
Mini-Reviews in Medicinal Chemistry Review of Clinic Trials: Agents Targeting c-Met
Reviews on Recent Clinical Trials Current Understanding of Epigenetics Driven Therapeutic Strategies in Colorectal Cancer Management
Endocrine, Metabolic & Immune Disorders - Drug Targets G-Protein Signaling, Lipid Rafts and the Possible Sites of Action for the Antidepressant Effects of n-3 Polyunsaturated Fatty Acids
CNS & Neurological Disorders - Drug Targets Targeting Long Non-Coding RNAs in Nervous System Cancers: New Insights in Prognosis, Diagnosis and Therapy
Current Medicinal Chemistry Antitumor Therapeutic Strategies Based on the Targeting of Epidermal Growth Factor-Induced Survival Pathways
Current Drug Targets Manipulation and Engineering of Metabolic and Biosynthetic Pathway of Plant Polyphenols
Current Pharmaceutical Design Biochemistry and Biology of 2'-Fluoro-2'-Deoxythymidine (FT), A Putative Highly Selective Substrate for Thymidine Kinase Type 2 (TK2)
Current Radiopharmaceuticals Emerging Roles of microRNAs in the Molecular Responses to Hypoxia
Current Pharmaceutical Design The Effect of Chemotherapy/Radiotherapy on Cancerous Pattern Recognition by NK Cells
Current Medicinal Chemistry The Role of CXC-Chemokine IL-8, IL-6 and CXCR2 Receptor in Lymphoplasmacytic Lymphoma: Correlations with Microvascular Characteristics and Clinical Features
Current Angiogenesis (Discontinued) Cdc25A Protein Phosphatase: A Therapeutic Target for Liver Cancer Therapies
Anti-Cancer Agents in Medicinal Chemistry Novel Natural and Synthetic Ligands of the Endocannabinoid System
Current Medicinal Chemistry Recent Developments in Anti-Cancer Agents Targeting the Ras/Raf/ MEK/ERK Pathway
Recent Patents on Anti-Cancer Drug Discovery Urokinase Receptor (uPAR) Ligand based Recombinant Toxins for Human Cancer Therapy
Current Pharmaceutical Design 7-Keto-Δ5-Steroids: Key-Molecules Owning Particular Biological and Chemical Interest
Mini-Reviews in Medicinal Chemistry Cancer Preventive Phytochemicals as Speed Breakers in Inflammatory Signaling Involved in Aberrant COX-2 Expression
Current Cancer Drug Targets The Potential of T Cell Immunoglobulin and Mucin-Domain Containing-3 (Tim-3) in Designing Novel Immunotherapy for Bladder Cancer
Endocrine, Metabolic & Immune Disorders - Drug Targets