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The Natural Products Journal


ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

Research Article

Potential Natural Dual Agonist PPARα/γ-induced Antidiabetic and Antidyslipidemic Properties of Safrole-Free Nutmeg Seed (Myristica fragrans Houtt) Extract

Author(s): Keri Lestari*, Ajeng Diantini, Melisa I. Barliana, Tri H. Achmad, Anas Subarnas, Mutakin, Rizky Abdulah, Ronny Lesmana and Jae K. Hwang

Volume 9 , Issue 3 , 2019

Page: [248 - 253] Pages: 6

DOI: 10.2174/2210315509666190206122849


Background: Nutmeg (Myristica fragrans Houtt) has the potential to control blood glucose and lipid levels. However, it contains safrole compounds, which are dangerous when humans consume them.

Objective: In this study, we eliminated safrole from nutmeg and investigated its antidiabetic and antidyslipidemic properties.

Methods: Nutmeg seeds were powdered, extracted with 90% ethanol, and chromatographed to remove the safrole. Safrole-free nutmeg extract was concentrated, and its antidiabetic and antidyslipidemic agents were tested in a type 2 diabetes mellitus rat model.

Results: The results showed that the blood glucose level decreased by 20% after 2 days of treatment, 30% after 4 days of treatment and 40% after 6 days of treatment with nutmeg extracts. The blood triglyceride level did not change in the first 2 days of treatment, and it decreased by 25% after 4 days of treatment and by another 25% after 6 days of treatment. Luciferase assay showed that safrole- free nutmeg increased the activities of PPAR α and γ in a dose-dependent manner, which marked the potential mechanism of lowering the triglyceride and glucose levels.

Conclusion: Results thus obtained are suggestive of the potential dual effect of safrole-free nutmeg extract on antidiabetic and antidyslipidemic management.

Keywords: Nutraceutical, nutmeg seed extract, antidiabetic, antidyslipidemic, PPARα/γ, diabetes mellitus.

Graphical Abstract
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