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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Peptide Sequence-Dominated Enzyme-Responsive Nanoplatform for Anticancer Drug Delivery

Author(s): Yanan Li, Liping Du, Chunsheng Wu, Bin Yu, Hui Zhang* and Feifei An*

Volume 19, Issue 1, 2019

Page: [74 - 97] Pages: 24

DOI: 10.2174/1568026619666190125144621

Price: $65


Enzymatic dysregulation in tumor and intracellular microenvironments has made this property a tremendously promising responsive element for efficient diagnostics, carrier targeting, and drug release. When combined with nanotechnology, enzyme-responsive drug delivery systems (DDSs) have achieved substantial advancements. In the first part of this tutorial review, changes in tumor and intracellular microenvironmental factors, particularly the enzymatic index, are described. Subsequently, the peptide sequences of various enzyme-triggered nanomaterials are summarized for their uses in various drug delivery applications. Then, some other enzyme responsive nanostructures are discussed. Finally, the future opportunities and challenges are discussed. In brief, this review can provide inspiration and impetus for exploiting more promising internal enzyme stimuli-responsive nanoDDSs for targeted tumor diagnosis and treatment.

Keywords: Tumor microenvironment, Enzyme-responsive, Peptide, Sequence, Targeted drug delivery, DDSs.

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