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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Pharmacotherapy of Vitreomacular Traction

Author(s): Ran Wan *, Thomas Hong, Yasser Tariq and Andrew Chang

Volume 24 , Issue 41 , 2018

Page: [4874 - 4881] Pages: 8

DOI: 10.2174/1381612825666190124102148

Price: $65


Vitreomacular traction occurs due to incomplete or anomalous posterior vitreous detachment. Over time, the vitreous pulls anteriorly and causes retinal distortion and eventually reduced vision. Traditionally, vitreomacular traction was treated with vitrectomy surgery. In the past few years, there is a paradigm shift towards pharmacologic vitreolysis, which involves the intravitreal injection of enzymatic and non-enzymatic agents that facilitate posterior vitreous detachment. Many agents have been investigated and trialled including plasmin, microplasmin (Ocriplasmin), hyaluronidase, nattokinase, chondroitinase and dispase. This review will focus on the progress and current status in this research.

Keywords: Vitreous, vitreomacular traction, vitreomacular adhesion, macular hole, posterior vitreous detachment, pharmacological vitreolysis, ocriplasmin.

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