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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Noncoding Rnas Emerging as Novel Biomarkers in Pancreatic Cancer

Author(s): Ingrid Garajová*, Rita Balsano, Chiara Tommasi and Elisa Giovannetti

Volume 24 , Issue 39 , 2018

Page: [4601 - 4604] Pages: 4

DOI: 10.2174/1381612825666190119125804

Price: $65


Noncoding RNAs play important regulatory roles in diverse biological processes and their misregulation might lead to different diseases, including cancer. Previous studies have reported the evolving role of miRNAs as new potential biomarkers in cancer diagnosis, prognosis, as well as predictive biomarkers of chemotherapy response or therapeutic targets. In this review, we outline the involvement of noncoding RNA in pancreatic cancer, providing an overview of known miRNAs in its diagnosis, prognosis and chemoresistance. In addition, we discuss the influence of non-coding RNAs in the metastatic behavior of pancreatic cancer, as well as the role of diet in epigenetic regulation of non-coding RNAs in cancer, which can, in turn, lead the development of new prevention’s techniques or novel targets for cancer therapy.

Keywords: Noncoding RNA, pancreatic cancer, biomarker, miRNAs, chemotherapy, epigenetic regulation.

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