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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Recent Advances on Cytotoxic Sesquiterpene Lactones

Author(s): José Quintana and Francisco Estévez*

Volume 24 , Issue 36 , 2018

Page: [4355 - 4361] Pages: 7

DOI: 10.2174/1381612825666190119114323

Price: $65

Abstract

Sesquiterpene lactones are naturally occurring compounds that have attracted considerable attention because to their vast array of biological activities. These plant-derived compounds contain the α-methylene-γ- butyrolactone functional group, which is the structural requirement for their pharmacological activities. Many of them exhibit cancer cell cytotoxicity and are promising anticancer agents through multiple mechanisms of action. Sesquiterpene lactones are alkylating agents that form covalent adducts in vivo and inhibit enzymes and key proteins. They are also potent apoptotic inducers in several cancer cells. This kind of cell death is recognized as a property that is useful for identifying anticancer drugs. This review focuses on the advances on cytotoxic sesquiterpene lactones and specifically the signal transduction pathways of cell death triggered in cancer cells.

Keywords: Sesquiterpene lactones, apoptosis, caspases, cytotoxicity, cell death, cell cycle arrest, mitogen-activated protein kinases, reactive oxygen species.


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