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Current Green Chemistry


ISSN (Print): 2213-3461
ISSN (Online): 2213-347X

Research Article

Catalyst-Free Glycerol Promoted Green Synthesis of 2-amino-1,8- naphthyridine -3-carbonitriles and 2-amino-3-quinolinecarbonitriles

Author(s): Km Neha Shivhare, Anushree Srivastava and Ibadur Rahman Siddiqui*

Volume 6, Issue 1, 2019

Page: [62 - 68] Pages: 7

DOI: 10.2174/2452273203666190114145322


We describe herein the use of glycerol as an efficient and sustainable approach for the synthesis of 2-amino-1, 8-naphthyridine-3-carbonitriles and 2-amino-3-quinolinecarbonitriles. The catalyst- free reactions occur straightforwardly using biodegradable and non-hazardous solvent. It is a strategy to address mounting environmental concerns with current approach includes the use of environmentally benign solvent, simple workup procedure, economic viability, shorter reaction time and providing good to excellent yield.

Keywords: Glycerol, naphthyridines, quinolines, biocatalyst, bio-renewable, eco-compatible.

Graphical Abstract
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