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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

MicroRNA-based Biosensors for Early Detection of Cancers

Author(s): Majid Rezayi*, Zahra Farjami, Zeinab S. Hosseini, Neshat Ebrahimi and Ebrahim Abouzari-Lotf

Volume 24 , Issue 39 , 2018

Page: [4675 - 4680] Pages: 6

DOI: 10.2174/1381612825666190111144525

Price: $65

Abstract

Small noncoding microRNAs (miRNAs) are known as noninvasive biomarkers for early detection in various cancers. In fact, miRNAs have key roles in carcinogenicity process such as proliferation, apoptosis and metastasis. After cardiovascular disease, cancer is the second cause of death in the world with an estimated 9.6 million deaths in 2018. So, early diagnosis of cancer is critical for successful treatment. To date, several selective and sensitive laboratory-based methods have been applied for the detection of circulating miRNA, but a simple, short assay time and low-cost method such as a biosensor method as an alternative approach to monitor cancer biomarker is required. In this review, we have highlighted recent advances in biosensors for circulating miRNA detection.

Keywords: Biosensor, cancer, diagnosis, biomarker, miRNA, carcinogenicity.


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