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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

The Prognostic and Predictive Value of microRNAs in Patients with H. pylori-positive Gastric Cancer

Author(s): Seyed Mostafa Parizadeh, Reza Jafarzadeh-Esfehani, Amir Avan*, Maryam Ghandehari, Fatemeh Goldani and Seyed Mohammadreza Parizadeh

Volume 24 , Issue 39 , 2018

Page: [4639 - 4645] Pages: 7

DOI: 10.2174/1381612825666190110144254

Price: $65


Gastric cancer (GC) has a high mortality rate with a poor 5-year survival. Helicobacter pylori (H. pylori) is present as part of the normal flora of stomach. It is found in the gastric mucosa of more than half of the world population. This bacterium is involved in developing H. pylori-induced GC due to the regulation of different micro ribonucleic acid (miRNA or miR). miRNAs are small noncoding RNAs and are recognized as prognostic biomarkers for GC that may control gene expression. miRNAs may function as tumor suppressors, or oncogenes. In this review, we evaluated studies that investigated the ectopic expression of miRNAs in the prognosis of H. pylori positive and negative GC.

Keywords: Gastric cancer, tissue mirna, Helicobacter pylori, normal flora, miRNA, gastric mucosa.

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