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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Prospective Plant Based Anticancer Lead Molecules

Author(s): Prabhjot Kaur and Vikas Sharma*

Volume 18 , Issue 30 , 2018

Page: [2567 - 2583] Pages: 17

DOI: 10.2174/1568026619666181224101132

Price: $65


Nature has been a source of a wide range of products being utilized for the treatment of various diseases like malaria, cancer, diabetes etc. Among these, cancer is emerging as a leading cause of deaths worldwide and the development of cross-resistance to already established drugs increases the need for novel anticancer drugs. To discover novel anticancer molecules, it is a necessity to unearth the molecules which can act as anticancer agents. Taking natural products in vision, phytoconstituents like terpenoids, flavones, glycosides and alkaloids might act as a major source of lead molecules. Considering the anticancer prospectives of phytoconstituents, different unknown lead molecules are summarized in this review. The present review highlights the representative studies of plant-based anticancer agents which are classified as per their phytochemical nature. Furthermore, important key points along with important structure-activity relationships points regarding selected lead molecules are also discussed.

Keywords: Abietane, Fucoxanthin, Obovatol, Phytoconstituents, Anticancer, Lead molecules, Terpenoids.

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