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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Research Article

Synthesis of (E)-vinyl Isobutyronitriles via Fe(III)-catalyzed Decarboxylative Cross-coupling of Cinnamic Acids and AIBN under Additive-free Conditions

Author(s): Xuemei Xu, Zaigang Luo*, Yuyu Fang and Peng Liu

Volume 16, Issue 8, 2019

Page: [656 - 661] Pages: 6

DOI: 10.2174/1570178616666181116112058

Price: $65


A facile, efficient, additive-free and eco-friendly protocol for the synthesis of (E)-vinyl isobutyronitriles via Fe(III)-catalyzed decarboxylative cross-coupling of cinnamic acids and AIBN (azodiisobutyronitrile) has been developed. The presented methodology offers several advantages such as easy accessibility and stability of substrates, inexpensive catalyst and simple post-treatment procedure.

Keywords: Decarboxylative cross-coupling, cinnamic acids, AIBN, vinyl isobutyronitriles, additives, heterocycle.

Graphical Abstract
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