Generic placeholder image

Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Review Article

Creatinine Deiminase: Characterization, Using in Enzymatic Creatinine Assay, and Production of the Enzyme

Author(s): Andriy Zakalskiy*, Nataliya Stasyuk and Mykhailo Gonchar

Volume 20, Issue 5, 2019

Page: [465 - 470] Pages: 6

DOI: 10.2174/1389203720666181114111731

Price: $65

Abstract

The goal of the review is description of the main characteristics of creatinine deiminase (CDI), an important bioanalytical tool for creatinine (Crn) assay. Crn is an essential metabolite for diagnostics of kidney disfunction and some other diseases, a biomarker to control the hemodialysis procedure, as well as an important analyte for sport medicine (estimation of general physiological status of athletes). We have described the important sources for CDI isolation, cloning of the corresponding gene, the construction of microbial recombinant strains, overproducing CDI, and characteristics of the enzyme from different microorganisms. There are reviewing also the new bioanalytical methods for quantitative determination of Crn, including enzymatic ones based on using CDI.

Keywords: Creatinine deiminase, protein characterization, gene cloning, enzyme isolation, creatinine, creatinine enzymatic assay.

[1]
Narayanan, S.; Appleton, H.D. Creatinine: A review. Clin. Chem., 1980, 26(8), 1119-1126.
[2]
Sant, W.; Pourciel-Gouzy, M.L.; Launay, J.; Do Conto, T.; Colin, R.; Martinez, A.; Temple-Boyer, P. Development of a creatinine-sensitive sensor for medical analysis. Sens. Actuators B Chem., 2004, 103, 260-264.
[3]
Wyss, M.; Kaddurah-Daouk, R. Creatine and creatinine metabolism. Phys. Rev., 2010, 80(3), 1107-1213.
[4]
Ceriotti, F.; Boyd, J.C.; Klein, G.; Henny, J.; Queralto, J.; Kairisto, V.; Panteghini, M. Reference intervals for serum creatinine concentrations: Assessment of available data for global application. Clin. Chem., 2008, 54(3), 559-566.
[5]
Lad, U.; Khokhar, S.; Kale, G.M. Electrochemical creatinine biosensors. Anal. Chem., 2008, 80(21), 7910-7917.
[6]
Purnima, D.S.; Rajeshwari, G.; Shivaprakash, T.M. Cystatin C – a novel marker of glomerular filtration rate. Indian J. Clin. Biochem., 2005, 20(1), 139-144.
[7]
Westhuyzen, J.; Cystatin, C. A promising marker and predictor of impaired renal function. Ann. Clin. Lab. Sci., 2006, 36(4), 387-394.
[8]
Murty, M.S.N.; Sharma, U.K.; Pandey, V.B.; Kankare, S.B. Serum cystatin C as a marker of renal function in detection of early acute kidney injury. Indian J. Nephrol., 2013, 23(3), 180-183.
[11]
Bleher, O.; Ehni, M.; Gauglitz, G. Label-free quantification of cystatin C as an improved marker for renal failure. Anal. Bioanal. Chem., 2012, 402(1), 349-356.
[12]
Gorodkiewicz, E.; Breczko, J.; Sankiewicz, A. Surface plasmon resonance imaging biosensor for cystatin determination based on the application of bromelain, ficin and chymopapain. Folia Histochem. Cytobiol., 2012, 50(1), 130-136.
[13]
Marchenko, S.V.; Zinchenko, O.A.; Poliakov, L.S.; Geleshko, A.M.; Dzyadevych, S.V.; Soldatkin, O.P. Biosensor based on creatinine deiminase and pH-sensitive field-effect transistor for creatinine analysis in blood serum. Biotechnologia Acta., 2013, 6(5), 79-86. [In Ukrainian].
[14]
Jaffe, M. Über den Niederschlag, welchen Pikrinsäure in normalem Harn erzeugt, und über eine neue Reaktion des Kreatinins. Z. Physiol. Chem., 1886, 10, 391-400.
[15]
Dobberpuhl Mo, Y.; Dash, A.K. A simple HPLC method with pulsed EC detection for the analysis of creatine. J. Pharm. Biomed. Anal., 2003, 32(1), 125-132.
[16]
Durán Merás, I.; Espinosa-Mansilla, A.; Rodriguez Gómes, M.J. Determination of methotrexate, several pteridines, and creatinine in human urine, previous oxidation with potassium permanganate, using HPLC with photometric and fluorimetric serial detection. Anal. Biochem., 2005, 346(2), 201-209.
[17]
George, S.K.; Dipu, M.T.; Mehra, U.R.; Verma, A.K.; Ramgaokar, J.S. Improved HPLC method for the simultaneous determination of allantoin, uric acid and creatinine in cattle urine. J. Chromatogr. B , 2006, 832(1), 134-137.
[18]
Samanidou, V.F.; Metaxa, A.S.; Paradoyannis, I.N. Direct simultaneous determination of uremic toxins: creatine, creatinine, uric acid, and xanthine in human biofluids by HPLC. J. Liq. Chromatogr. A., 2002, 25(1), 43-57.
[19]
Yao, T.; Kotegawa, K. Simultaneous flow-injection assay of creatinine and creatine in serum by the combined use of a 16-way switching valve, some specific enzyme reactors and a highly selective hydrogen peroxide electrode. Anal. Chim. Acta, 2002, 462, 283-291.
[20]
Yokoyama, Y.; Horikoshi, S.; Takahashi, T.; Sato, H. Low-capacity cation-exchange chromatography of ultraviolet-absorbing urinary basic metabolites using a reversed-phase column coated with hexadecylsulfonate. J. Chromatogr. A, 2000, 886(1-2), 297-302.
[21]
Yokoyama, Y.; Tsuji, S.; Sato, H. Simultaneous determination of creatinine, creatine, and UV-absorbing amino acids using dual-mode gradient low-capacitycation-exchange chromatography. J. Chromatogr. A, 2005, 1085(1), 110-116.
[22]
Burke, D.G.; MacLean, P.G.; Walker, R.A.; Dewar, P.J.; Smith‐Palmer, T. Analysis of creatine and creatinine in urine by capillary electrophoresis. J. Chromatogr. B , 1999, 732, 479-485.
[23]
Tran, T.C.; Huq, T.A.; Kantes, H.L.; Crane, J.N.; Strein, T.G. Determination of creatinine and other uremic toxins in human blood sera with micellar electrokinetic capillary electrophoresis. J. Chromatogr B., 1997, 690(1-2), 35-42.
[24]
Pobozy, E.; Radomska, A.; Koncki, R. Głab, S. Determination of dialysate creatinine by micellar electrokinetic chromatography. J. Chromatogr. B , 2003, 789, 417-424.
[25]
Zinellu, A.; Sotgia, S.; Zinellu, E.; Chessa, R.; Deiana, L.; Carru, C. Assay for the simultaneous determination of guanidinoacetic acid, creatinine and creatine in plasma and urine by capillary electrophoresis UV-detection. J. Sep. Sci., 2006, 29(5), 704-708.
[26]
Tuma, P.; Samcova, E.; Balinova, P. Determination of 3-methylhistidine and 1-methylhistidine in untreated urine samples by capillary electrophoresis. J. Chromatogr. B, 2005, 821(1), 53-59.
[27]
Rodrigues, J.; Berzas, J.J. Castaneda, Mora G.N.; Rodríguez M.J. Very fast and direct capillary zone electrophoresis method for the determination of creatinine and creatine in human urine. Anal. Chim. Acta, 2004, 521(1), 53-59.
[28]
Zinellu, A.; Caria, M.A.; Tavera, C.; Sotgia, S.; Chessa, R.; Deiana, L.; Carru, C. Plasma creatinine and creatine quantification by capillary electrophoresis diode array detector. Anal. Biochem., 2005, 342(2), 186-193.
[29]
Costa, A.C.O.; da Costa, J.L.; Tonin, F.G.; Tavares, M.F.M.; Micke, G.A. Development of a fast capillary electrophoresis method for determination of creatinine in urine samples. J. Chromatogr. A, 2007, 1171(1), 140-143.
[30]
Kvasnicka, F.; Voldrich, M. Isotachophoretic determination of creatinine in meat and meat products. Electrophoresis, 2000, 21, 2848-2850.
[31]
Huskova, R.; Chrastina, P.; Adam, T.; Schneiderka, P. Determination of creatinine in urine by tandem mass spectrometry. Clin. Chim. Acta, 2004, 350(1-2), 99-106.
[32]
Zinchenko, O.A.; Marchenko, S.V.; Sergeyeva, T.A.; Kukla, A.L.; Pavlyuchenko, A.S.; Krasyuk, E.K.; Soldatkin, A.P.; El’skaya, A.V. Application of creatinine-sensitive biosensor for hemodialysis control. Biosens. Bioelectron., 2012, 35, 466-469.
[33]
Gottschalk, E.M.; Gottschalk, G.; Delitz, R.P.; Holdt-Lehmann, B.; Thormann, K.; Schmitz-Streit, R. A new creatinine assay destined to become routine. Renal Disease, www.cli-online.com/fileadmin/artimg/a-new-creatinine-assay-destined-to-become-routine.pdf As published in CLI October, 2005).
[34]
Shimizu, S.; Kim, J.M.; Yamada, H. Microbial enzymes for creatinine assay: A review. Clin. Chim. Acta, 1989, 185(3), 241-252.
[39]
Szulmajster, J. Bacterial fermentation of creatinine I. Isolation of N-Methyl-Hydantoin. J. Bacteriol., 1958, 75(6), 633-639.
[40]
Szulmajster, J. Bacterial degradation of creatinine: II. Creatinine desimidase. Biochim. Biophys. Acta, 1958, 30(1), 154-163.
[41]
Kim, J.M.; Shimizu, S.; Yamada, H. Cytosine deaminase that hydrolyzes creatinine to N-methylhydantoin in various cytosine deaminase-forming microorganisms. Arch. Microbiol., 1987, 147, 58-63.
[42]
Esders, T.W.; Lynn, S.Y. Purification and properties of creatinine iminohydrolase from Flavobacterium filamentosum. J. Biol. Chem., 1985, 260(7), 3915-3922.
[43]
Katsuragi, T.; Sonoda, T.; Matsumoto, K.; Sakai, T.; Tonomura, K. Purification and some properties of cytosine deaminase from bakers’ yeast. Agric. Biol. Chem., 1989, 53(5), 1313-1319.
[44]
Uwajima, T.; Terada, O. Properties of crystalline creatinine deiminase from Corynebacterium lilium. Agric. Biol. Chem., 1980, 44(8), 1787-1792.
[45]
Hermann, M.; Knerr, H.J.; Mai, N.; Gross, A.; Kaltwasser, H. Creatinine and N-methylhydantoin degradation in two newly isolated Clostridium species. Arch. Microbiol., 1992, 157(5), 395-401.
[46]
Kim, J.M.; Shimizu, S.; Yamada, H. Evidence for the presence of cytosine deaminase that does not catalyze the deimination of creatine. FEBS Lett., 1987, 210(1), 77-80.
[47]
Gottschalk, E.M.; Hippe, H.; Patzke, F. Creatinine deiminase (EC 3.5.4.21) from bacterium BN11: Purification, properties and applicability in a serum/urine creatinine assay. Clin. Chim. Acta, 1991, 204(1-3), 223-238.
[48]
Ipata, P.L.; Marmocchi, F.; Magni, G.; Felicioli, R.; Polidoro, G. Baker’s yeast cytosine deaminase. Some enzymic properties and allosteric inhibition by nucleosides and nucleotides. Biochemistry, 1971, 10(23), 4270-4276.
[49]
Katsuragi, T.; Sakai, T.; Tonomur, K. Affinity chromatography of cytosine deaminase from Escherichia coli with immobilized pyrimidine compounds. Agric. Biol. Chem., 1986, 50(7), 1713-1719.
[50]
Austin, E.A. Huber, B.E. A first step in the development of gene therapy for colorectal carcinoma: Cloning, sequencing, and expression of Escherichia coli cytosine deaminase. Mol. Pharmacol., 1993, 43, 380-387.
[51]
Kalinowski, J.; Bathe, B.; Bartels, D.; Bischoff, N.; Bott, M.; Burkovski, A.; Dusch, N.; Eggeling, L.; Eikmanns, B.J.; Gaigalat, L.; Goesmann, A.; Hartmann, M.; Huthmacher, K.; Krämer, R.; Linke, B.; McHardy, A.C.; Meyer, F.; Möckel, B.; Pfefferle, W.; Pühler, A.; Rey, D.A.; Rückert, C.; Rupp, O.; Sahm, H.; Wendisch, V.F.; Wiegräbe, I.; Tauch, A. The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins. J. Biotechnol., 2003, 104(1-3), 5-25.
[52]
Bendt, A.K.; Beckers, G.; Silberbach, M.; Wittmann, A.; Burkovski, A. Utilization of creatinine as an alternative nitrogen source in Corynebacterium glutamicum. Arch. Microbiol., 2004, 181, 443-450.
[53]
Uwajima, T.; Terada, O. Crystallization and some properties of creatinine deiminase from Corynebacterium lilium. Agric. Biol. Chem., 1976, 40, 1055-1056.
[54]
Uwajima, T.; Terada, O. Production, purification and crystallization of creatinine deaminase of Corynebacterium lilium. Agric. Biol. Chem., 1977, 41, 339-344.
[55]
Tabata, M.; Kido, T.; Totani, M.; Murachi, T. Automated assay of creatinine in serum as simplified by the use of immobilized enzymes, creatinine deiminase, and glutamate dehydrogenase. Anal. Biochem., 1983, 134, 44-49.
[61]
Gonchar, M.; Zakalskiy, A.; Rzhepetskyy, Y.; Hryniv, O. Recombinant microbial creatinine deiminase as a bioanalytical tool. In: , FEBS Journal , Proceedings of the FEBS Conference Book, Paris, France, 30 August - 4 September. 2014, Vol. 281 (Suppl. 1), p. 595
[62]
Stasyuk, N.; Zakalskiy, A.; Zakalska, O.; Gonchar, M. His)6-tagged Corynebacterium glutamicum creatinine deiminase as a biosensing element for creatinine assay.In: Weigl Conference Book, Proceedings of the 7th International Weigl Conference, Lviv, Ukraine, September 26-29,. 2017. Sibirny, A.A. Ed.; Lviv Univ., USA, 2017; p. 34.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy