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Current Signal Transduction Therapy

Editor-in-Chief

ISSN (Print): 1574-3624
ISSN (Online): 2212-389X

Research Article

Computational Modeling of Dielectrophoretic Microfluidic Channel for Simultaneous Separation of Red Blood Cells and Platelets

Author(s): S. Praveenkumar*, S. Nath Srigitha, Ram G. Dinesh and R. Ramesh

Volume 15 , Issue 3 , 2020

Page: [243 - 251] Pages: 9

DOI: 10.2174/1574362413666181102113636

Abstract

Background: In this paper, the design and computational modeling of microfluidic channel capable of separating platelets and Red Blood Cell (RBC) from the other blood cells are proposed.

Materials and Methods: Separation based on their sizes is made possible by utilizing negative dielectrophoretic (n-DEP) force in fusion with drag force. An array of 38º angled electrode separated by 70 μm distance is designed within the microchannel and analyzed for non-uniform electric field distribution.

Results and Conclusion: The molecule movement within the microchannel under induced electric field is simulated to demonstrate the separation using the particle trajectories module. A numerical study is performed for the calculation of Clausius Mossotti (CM) factor, n-DEP force and drag force.

Keywords: Microfluidics, biomolecule separation, dielectrophoresis, computational modeling, RBC, platelets.

Graphical Abstract

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