Cascade Synthesis with (Triphenylphosphoranylidene)-Ethenone as a Versatile Reagent for Fast Synthesis of Heterocycles and Unsaturated Amides under Microwave Dielectric Heating

Title: Cascade Synthesis with (Triphenylphosphoranylidene)-Ethenone as a Versatile Reagent for Fast Synthesis of Heterocycles and Unsaturated Amides under Microwave Dielectric Heating

Volume: 5 Issue: 7

Author(s): J. Westman and K. Orrling

Affiliation:

Keywords: Microwave heating, one-pot synthesis, cascade reaction, library synthesis, (triphenylphosphoranylidene)ethenone

Abstract: A general procedure for the synthesis of a large variety of compounds comprising an α, β-unsaturated carbonyl functionality was developed. The use of one-pot cascade synthesis with (triphenylphosphoranylidene) ethenone as a versatile reagent for various formations including heterocycles of different ring sizes and unsaturated amides in combination with microwave dielectric heating is described. The method was used to synthesize a small library of unsaturated amides.

Cite this article as:

J. Westman and K. Orrling , Cascade Synthesis with (Triphenylphosphoranylidene)-Ethenone as a Versatile Reagent for Fast Synthesis of Heterocycles and Unsaturated Amides under Microwave Dielectric Heating, Combinatorial Chemistry & High Throughput Screening 2002; 5 (7) . https://dx.doi.org/10.2174/1386207023330066