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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Review Article

Breakthroughs in Venom Peptide Screening Methods to Advance Future Drug Discovery

Author(s): Tanya Napolitano and Mandë Holford*

Volume 25, Issue 12, 2018

Page: [1137 - 1148] Pages: 12

DOI: 10.2174/0929866525666181101103047

Price: $65


Background: Venom peptides are a proven resource for identifying novel drugs, however the process of identifying bioactive venom peptides is currently labor intensive, costly, and rarely results in pharmaceutical success. As venom peptides are modulators of ion channels and receptors their potential for manipulating cell signals in diseased states are unique and offer an untapped resource for finding new medicines. Recent advances in -omic technologies, and microfluidic biosensing systems have transformed how venom peptides are discovered and characterized.

Conclusion: This review will cover past, present and future approaches for screening venom peptides for drug discovery and development. Specifically, we will highlight online high-resolution microfluidic biosensing systems and new fluorescence detection methods that can be adapted to expand the discovery and characterization of venom peptide drugs.

Keywords: Venom, peptides, microfluidics, drug discovery, biosensing, bioassays, high-resolution screening.

Graphical Abstract

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