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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Research Article

Synthesis and Evaluation of Aromatic Surfactants as Potential Antibacterial and Cytotoxic Agents

Author(s): Kenia Barrantes, Mary Fuentes, Luz Chacón, Rosario Achí, Jorge Granados-Zuñiga, María José Alvarado, Luis Somarribas, José Vázquez-Tato, M. Pilar Vázquez-Tato, Julio A. Seijas and Víctor Soto Tellini*

Volume 16, Issue 6, 2019

Page: [478 - 484] Pages: 7

DOI: 10.2174/1570178615666181023151308

Price: $65

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Abstract

Two ether and one ester derivatives of the 4-nitro-3-hydroxybenzoic acid were synthesized and characterized. The in vitro antimicrobial and cytotoxic activities of the three novel compounds were also evaluated. The aromatic derivatives showed antibacterial activity against one of the four microorganisms tested and two compounds (C8 and NOBA) had a lower IC50 in HeLa cells.

Keywords: Surfactants, cytotoxic activity, antimicrobial activity, aromatic, 4-nitro-3-hidroxybenzoic acid, organic chemistry.

Graphical Abstract
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