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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Research Article

One New C21 Steroidal Glycosides from the Leaves of Cynanchum hancockianum

Author(s): Shubei Yu, Xixi Lin, Yi Zheng, Zheng Wu, Wei Zheng and Liman Qiao*

Volume 16, Issue 7, 2019

Page: [556 - 559] Pages: 4

DOI: 10.2174/1570178615666181016113531

open access plus


C21 steroids glycosides of various deoxysugars have been emerging from genus of Cynanchum. Besides classical C21 glycosides, many C21 glycosides with seco-ring aglycones attracted the extensive attention of many researchers. We conducted a systematic chemical investigation on Cynanchum hancockianum, which led to the isolation of one new seco-ring C21 steroidal glycosides. The new compound was identified as cynaascyriogenin 3-O-β-D-glucopyranosyl-(1-4)-α-L-cymaropyranosy-(1-4)- β-D-cymaropyranosyl-(1-4)-β-D-cymaropyranoside. The cytotoxic activities of the compound were evaluated using the A549 and MCF-7 cell lines, respectively. The IC50 values of the compound were 41.3 and 67.1µM, respectively. This is the first report on the isolation of seco-ring C21 steroidal glycosides from Cynanchum hancockianum.

Keywords: Cynanchum hancockianum, C21 steroids, glycoside, deoxysugars, nuclear magnetic resonance, cytotoxic activity.

Graphical Abstract
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