Abstract
Hematopoiesis is a complex process during which hematopoietic stem cells (HSC) proliferate and differentiate to constitute both the myeloid and lymphoid branches of the hematopoietic system. Hematopoiesis occurs in successive organs beginning in the yolk sac and aorto-gonads-mesonephros (AGM) region, then migrate from the AGM region to the fetal liver and subsequently to the bone marrow. Hematopoiesis is regulated by a multitude of signals from the microenvironment that control expansion and proper differentiation of blood progenitors. Modifications in gene expression or protein function, as those occurring by chromosome translocations have an oncogenic potential. Over the last decade an increasing number of recurrent chromosomal translocations has been described that are associated with hematologic malignancies. Cloning of the partner genes in these translocations and molecular abnormalities characterization has provided new insights in the processes involved in both normal and malignant hematopoiesis. We review here some of the translocations involved in the pathogenesis of hematologic malignancies with emphasis on what is known regarding the mechanisms of malignant transformation.
Keywords: hematologic malignancy, chromosomal translocation, bcr / abl fusion, tel / abl fusion, hox gene
Call for Papers in Thematic Issues
Advanced AI Techniques in Big Genomic Data Analysis
The thematic issue on "Advanced AI Techniques in Big Genomic Data Analysis" aims to explore the cutting-edge methodologies and applications of artificial intelligence (AI) in the realm of genomic research, where vast amounts of data pose both challenges and opportunities. This issue will cover a broad spectrum of AI-driven strategies, ...read more
Advances in Genomics and Precision Medicine for Cardiovascular Diseases
Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality globally, representing a significant challenge to public health systems. Recent advancements in genomics and precision medicine offer unprecedented opportunities to transform the prevention, diagnosis, and treatment of CVDs. This special issue of Current Genomics explores the latest developments in ...read more
AI-Driven Genomics and Multi-Omics Approaches for Drug Discovery and Precision Medicine
The rapid advancements in artificial intelligence (AI) have opened new avenues in genomics and multi-omics research, providing transformative insights into disease mechanisms, biomarker discovery, and therapeutic strategies. This thematic issue explores the intersection of AI with genomics, transcriptomics, proteomics, metabolomics, and epigenomics, focusing on how computational intelligence can facilitate data ...read more
Emerging Molecular Mechanisms in Rare Genetic Skeletal Disorders: Linking Genomic Mutations to Clinical Outcomes.
Rare genetic skeletal disorders encompass a diverse group of conditions that impact bone and cartilage development, often due to pathogenic mutations in critical developmental genes. This thematic issue aims to explore the intricate molecular mechanisms underlying these disorders, providing insights into how specific genomic mutations translate into clinical phenotypes. Recent ...read more
Related Journals
Related Books
Arid and Semi-Arid Zones of Mexico: A Comprehensive Exploration of Biodiversity, Ecology, and Conservation
Wild Vegetables: Morphology, Phytochemistry and Utility Part 1
Biology for Students
Medicinal Plants of Pilibhit Tiger Reserve (PTR) India
Plant-Microbe Interactions: A Comprehensive Review
Glycosylation and Glycation in Health and Diseases
Phytogenic and Phytochemical as Alternative Feed Additives for Animal Production
Methods and Techniques in Nematology
Mind Maps in Clinical Biochemistry
A Treatise on Ecological Science
2
