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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Goniothalamin-Related Styryl Lactones: Isolation, Synthesis, Biological Activity and Mode of Action

Author(s): Ronaldo Aloise Pilli*, Ian de Toledo, Matheus Andrade Meirelles and Thiago Augusto Grigolo

Volume 26, Issue 41, 2019

Page: [7372 - 7451] Pages: 80

DOI: 10.2174/0929867325666181009161439

Price: $65


This review covers the chemistry and biological aspects of goniothalamin-related styryl lactones isolated from natural sources. This family of secondary metabolites has been reported to display diverse uses in folk medicine, but only a limited number of these compounds have been throughly investigated regarding their biological profile. Herein, we cover the goniothalamin-related styryl lactones having a C6-C3-C4 framework which appeared in the literature for the first time in the period 2000-2017, and the reports on the synthesis, biological activity and mechanism of action which were published from 2007-2017.

Keywords: Goniothalamin, styryl lactones, isolation, synthesis, biological activity, mode of action.

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